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WeighLab

Enhance MD vs OnlyRx

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Enhance MD

Affiliate partner

Shoppers who want flat pricing that doesn't rise with the dose, routine lab monitoring and a semaglutide-plus-tirzepatide combo option, and who don't need a brand-name or oral route.

Semaglutide / month
$212/moFirst month $112
Tirzepatide / month
$280/moFirst month $180
Index 76/100 · Grade CChecked October 2026

OnlyRx

Provider comparison

Shoppers who want a 50-state marketplace with multiple pharmacy options and named prescribers.

Semaglutide / month
$179/moStarting dose, compounded
Tirzepatide / month
$249/moStarting dose, compounded
Index 77/100 · Grade CChecked October 2026

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

OnlyRx has the higher Cost-Efficiency Index: 77/100 versus 76/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

Enhance MD
40 states + DC
OnlyRx
All 50 states

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Enhance MD

OnlyRx

Semaglutide / month
Enhance MD: $212/moFirst month $112
OnlyRx: $179/moStarting dose, compounded
Tirzepatide / month
Enhance MD: $280/moFirst month $180
OnlyRx: $249/moStarting dose, compounded
Semaglutide / year (modeled)
Enhance MD: $2,544
OnlyRx: $2,148
Tirzepatide / year (modeled)
Enhance MD: $3,360
OnlyRx: $2,988
State availability
Enhance MD: 40 states + DC
OnlyRx: All 50 states
Oral / sublingual option listed
Enhance MD: Not listed
OnlyRx: Yes
Brand-name access listed
Enhance MD: Not confirmed
OnlyRx: Yes
Provider facts checked
Enhance MD: October 2026
OnlyRx: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Enhance MD

Shoppers who want flat pricing that doesn't rise with the dose, routine lab monitoring and a semaglutide-plus-tirzepatide combo option, and who don't need a brand-name or oral route.

Reasons to consider it

  • Every plan is priced on the homepage before any quiz: semaglutide $212, tirzepatide $280, a semaglutide-plus-tirzepatide combo $322 and microdosed tirzepatide $169
  • The monthly price stays the same as your dose goes up
  • Lab testing every six months and ongoing provider messaging are built into the price rather than sold separately

What to weigh up

  • Compounded only, with no brand-name Wegovy, Ozempic, Mounjaro or Zepbound
  • No oral or sublingual GLP-1, so every option is an injection
  • The $112 and $180 on the homepage are first-month prices; from month two you pay $212 and $280

OnlyRx

Shoppers who want a 50-state marketplace with multiple pharmacy options and named prescribers.

Reasons to consider it

  • Says it serves all 50 states
  • Names physicians at Lion MD with public NPI numbers
  • Lists four pharmacy partners with contact information

What to weigh up

  • The banner still calls $179 a Summer Promo, while product cards say starting at; confirm the ongoing rate
  • No dose-by-dose price list is published
  • Ask which of the four pharmacy partners will fill your prescription

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Enhance MDOnlyRx
Normalized Cost/Month
Enhance MD:
65/100
OnlyRx:
68/100
Price Transparency
Enhance MD:
88/100
OnlyRx:
84/100
Nationwide Access
Enhance MD:
66/100
OnlyRx:
86/100
Formulation Options
Enhance MD:
74/100
OnlyRx:
90/100
Clinical Oversight
Enhance MD:
85/100
OnlyRx:
72/100
Contract Flexibility
Enhance MD:
82/100
OnlyRx:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

Keep comparing

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.