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WeighLab

Direct Meds vs MyFastRx

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Direct Meds

Affiliate partner

Needle-averse shoppers who want a sublingual route on either molecule and will pay above the going rate for it, having accepted a three-month supply as the smallest unit sold.

Semaglutide / month
$249/moSublingual, 90-day supply billed monthly
Tirzepatide / month
$299/moSublingual, 90-day supply billed monthly
Index 71/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Direct Meds pricing Read review

MyFastRx

Provider comparison

Cash-pay shoppers comfortable prepaying several months up front to get MyFastRx's lowest per-month compounded GLP-1 rate.

Semaglutide / month
$139/moAll doses, promotional rate, compounded
Tirzepatide / month
$199/moAll doses, promotional rate, compounded
Index 73/100 · Grade CChecked August 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check MyFastRx pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

MyFastRx has the higher Cost-Efficiency Index: 73/100 versus 71/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

Direct Meds
Not disclosed
MyFastRx
All 50 states

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Direct Meds

MyFastRx

Semaglutide / month
Direct Meds: $249/moSublingual, 90-day supply billed monthly
MyFastRx: $139/moAll doses, promotional rate, compounded
Tirzepatide / month
Direct Meds: $299/moSublingual, 90-day supply billed monthly
MyFastRx: $199/moAll doses, promotional rate, compounded
Semaglutide / year (modeled)
Direct Meds: $2,988
MyFastRx: $1,668
Tirzepatide / year (modeled)
Direct Meds: $3,588
MyFastRx: $2,388
State availability
Direct Meds: Not disclosed
MyFastRx: All 50 states
Oral / sublingual option listed
Direct Meds: Yes
MyFastRx: Not listed
Brand-name access listed
Direct Meds: Not confirmed
MyFastRx: Not confirmed
Provider facts checked
Direct Meds: October 2026
MyFastRx: August 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Direct Meds

Needle-averse shoppers who want a sublingual route on either molecule and will pay above the going rate for it, having accepted a three-month supply as the smallest unit sold.

Reasons to consider it

  • Sublingual and injection on both molecules, so four GLP-1 products to choose from
  • Every price is published per SKU in a public shop, with no quiz, intake or email capture in front of it
  • Each product page prints a per-day equivalent beside the monthly rate ($8.03/day at $249), which is unusually concrete for this category

What to weigh up

  • $249 a month for the sublingual and $297 for the injection cost more than many programs we track charge for an injection
  • The only purchasable option on every product page is a 90-DAY SUPPLY billed monthly, so three months is the smallest unit sold — there is no month-to-month rate to compare with programs you can cancel after one month
  • Every headline figure is framed "AS LOW AS", yet the only available option shows "0% OFF" — the framing implies a cheaper tier that is not actually on sale

Regulatory note: the FDA issued a warning letter to directmeds.com, Inc. dba DirectMeds in September 2025. We still list and link to Direct Meds; you should know the letter is on the public record before you decide.

Compounded drugs are not FDA-approved. Understand the medication options.

Check Direct Meds pricing Read the full Direct Meds review

MyFastRx

Cash-pay shoppers comfortable prepaying several months up front to get MyFastRx's lowest per-month compounded GLP-1 rate.

Reasons to consider it

  • Publishes a full, specific price ladder (1/3/6/12-month) rather than a single vague 'starting at' figure
  • LegitScript certified
  • Flat pricing across all doses — no dosage upcharges as you titrate

What to weigh up

  • The true no-commitment monthly rate ($139 sema / $199 tirz) is meaningfully higher than the deep prepay-bundle rates the marketing emphasizes ($79-99 / $124-166) — those low numbers require paying for 3, 6, or 12 months upfront
  • The lowest first-month price ($69 / $129) requires entering a promo code and applies to one month only
  • Doesn't list the states it serves, only 'multiple states / licensed U.S. providers', so check yours before you start

Compounded drugs are not FDA-approved. Understand the medication options.

Check MyFastRx pricing Read the full MyFastRx review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Direct MedsMyFastRx
Normalized Cost/Month
Direct Meds:
62/100
MyFastRx:
73/100
Price Transparency
Direct Meds:
78/100
MyFastRx:
94/100
Nationwide Access
Direct Meds:
60/100
MyFastRx:
86/100
Formulation Options
Direct Meds:
96/100
MyFastRx:
66/100
Clinical Oversight
Direct Meds:
68/100
MyFastRx:
66/100
Contract Flexibility
Direct Meds:
66/100
MyFastRx:
33/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.