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WeighLab

Amble vs Open Water Rx

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Amble

Provider comparison

Cost-first shoppers who want a single flat rate across semaglutide and tirzepatide, if a 3- or 6-month prepay is acceptable.

Semaglutide / month
$179/moAll doses, compounded
Tirzepatide / month
$179/moAll doses, compounded
Index 78/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Amble pricing Read review

Open Water Rx

Provider comparison

Shoppers who want published monthly all-dose injection prices and separate oral options.

Semaglutide / month
$169/moAll doses, monthly compounded injection program
Tirzepatide / month
$219/moAll doses, monthly compounded injection program
Index 78/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Open Water Rx pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Both score 78/100 on the Cost-Efficiency Index. There is no score winner; compare the treatment you need, billing terms and state availability.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Amble

Open Water Rx

Semaglutide / month
Amble: $179/moAll doses, compounded
Open Water Rx: $169/moAll doses, monthly compounded injection program
Tirzepatide / month
Amble: $179/moAll doses, compounded
Open Water Rx: $219/moAll doses, monthly compounded injection program
Semaglutide / year (modeled)
Amble: $2,148
Open Water Rx: $2,028
Tirzepatide / year (modeled)
Amble: $2,148
Open Water Rx: $2,628
State availability
Amble: All 50 states
Open Water Rx: All 50 states
Oral / sublingual option listed
Amble: Not listed
Open Water Rx: Yes
Brand-name access listed
Amble: Not confirmed
Open Water Rx: Not confirmed
Provider facts checked
Amble: October 2026
Open Water Rx: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Amble

Cost-first shoppers who want a single flat rate across semaglutide and tirzepatide, if a 3- or 6-month prepay is acceptable.

Reasons to consider it

  • One price at every dose: $179 month to month, $160 a month on a 3-month plan, $135 on a 6-month plan
  • True no-commitment option exists ($179/mo, pay as you go) alongside the prepay plans
  • All 50 states, with only 5 requiring a live video visit instead of async intake

What to weigh up

  • The advertised low-end price ($135-$160/mo) is not a monthly bill — the whole 3- or 6-month plan is charged at purchase and can't be refunded once medication ships
  • Amble says 'all 50 states (exclusions apply)' but doesn't list the exclusions
  • Amble sells 'compounded GLP-1' without naming semaglutide or tirzepatide, so ask which one you'd be prescribed

Compounded drugs are not FDA-approved. Understand the medication options.

Check Amble pricing Read the full Amble review

Open Water Rx

Shoppers who want published monthly all-dose injection prices and separate oral options.

Reasons to consider it

  • One-month injection plans have no dose-based price increase
  • Clinical review, medication if prescribed, shipping and follow-up are included
  • Oral semaglutide and tirzepatide have separate published prices

What to weigh up

  • Multi-month plans require prepayment; confirm the total before buying
  • Cancel at least 72 hours before the next billing date
  • The homepage says no charge before approval, while its cancellation policy describes payment at checkout and a refund if declined

Compounded drugs are not FDA-approved. Understand the medication options.

Check Open Water Rx pricing Read the full Open Water Rx review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

AmbleOpen Water Rx
Normalized Cost/Month
Amble:
75/100
Open Water Rx:
81/100
Price Transparency
Amble:
94/100
Open Water Rx:
94/100
Nationwide Access
Amble:
86/100
Open Water Rx:
86/100
Formulation Options
Amble:
66/100
Open Water Rx:
77/100
Clinical Oversight
Amble:
79/100
Open Water Rx:
59/100
Contract Flexibility
Amble:
55/100
Open Water Rx:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

Keep comparing

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.