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WeighLab

1st Optimal vs Defy Medical

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

1st Optimal

Provider comparison

Patients who want a named founding physician and a broader functional-medicine/hormone workup alongside GLP-1s.

Semaglutide / month
Not disclosed
Tirzepatide / month
Not disclosed
Index 44/100 · Grade CChecked October 2026

Defy Medical

Provider comparison

Men already in TRT or hormone care who want to add a GLP-1 with the same clinic, rather than shoppers comparing GLP-1 prices alone.

Semaglutide / month
Not disclosed
Tirzepatide / month
Not disclosed
Index 43/100 · Grade CChecked August 2026

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

1st Optimal has the higher Cost-Efficiency Index: 44/100 versus 43/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

1st Optimal

Defy Medical

Semaglutide / month
1st Optimal: Not disclosed
Defy Medical: Not disclosed
Tirzepatide / month
1st Optimal: Not disclosed
Defy Medical: Not disclosed
Semaglutide / year (modeled)
1st Optimal: —
Defy Medical: —
Tirzepatide / year (modeled)
1st Optimal: —
Defy Medical: —
State availability
1st Optimal: Coverage not published
Defy Medical: Coverage not published
Oral / sublingual option listed
1st Optimal: Yes
Defy Medical: Yes
Brand-name access listed
1st Optimal: Not confirmed
Defy Medical: Not confirmed
Provider facts checked
1st Optimal: October 2026
Defy Medical: August 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

1st Optimal

Patients who want a named founding physician and a broader functional-medicine/hormone workup alongside GLP-1s.

Reasons to consider it

  • Named founder and clinical lead: Dr. Amber Miller, a functional medicine physician
  • LegitScript verification badge displayed
  • No credit card required to start the intake quiz

What to weigh up

  • The membership is not the medication price; request a dose-specific drug quote and any lab charges
  • The public plan page now starts with a $39 Optimal Health membership rather than a separate published $99 Weight Loss Care plan
  • The dispensing pharmacy and treatment-specific state list are not published

Defy Medical

Men already in TRT or hormone care who want to add a GLP-1 with the same clinic, rather than shoppers comparing GLP-1 prices alone.

Reasons to consider it

  • Named, credentialed Medical Director (Dr. Justin Saya)
  • Large third-party review base (3,999 Trustpilot reviews, 5-star average)
  • Offers both semaglutide and tirzepatide alongside broader men's-health services

What to weigh up

  • GLP-1 is clearly a secondary offering bolted onto a primarily TRT/hormone-optimization practice, not its core focus
  • Zero pricing disclosed on its site -- fully gated behind quiz/consultation
  • No LegitScript certification

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

1st OptimalDefy Medical
Normalized Cost/Month
1st Optimal:
45/100
Defy Medical:
45/100
Price Transparency
1st Optimal:
20/100
Defy Medical:
20/100
Nationwide Access
1st Optimal:
24/100
Defy Medical:
24/100
Formulation Options
1st Optimal:
51/100
Defy Medical:
56/100
Clinical Oversight
1st Optimal:
84/100
Defy Medical:
80/100
Contract Flexibility
1st Optimal:
61/100
Defy Medical:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

Keep comparing

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.