Head-to-head · Cost-Efficiency Index
YourEra vs Cost Plus Drugs
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
YourEra
Shoppers chasing the lowest sticker price who will verify what's actually billed after the first month.
Visit YourEraCost Plus Drugs
Cost-first shoppers who want the cheapest transparent-pricing brand-name Ozempic channel.
Visit Cost Plus DrugsThe verdict
Cost Plus Drugs takes it, leading the Cost-Efficiency Index 64 to 62. Mark Cuban's transparent-pricing online pharmacy. YourEra still earns a C — Shoppers chasing the lowest sticker price who will verify what's actually billed after the first month.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Cost Plus Drugs.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | YourEra | Cost Plus Drugs |
|---|---|---|
| Cost-Efficiency Index | 62/100 | 64/100 |
| Semaglutide / mo | $179/mo (all doses, month-to-month, compounded) | $279/mo (brand Ozempic) |
| Tirzepatide / mo | $259/mo (all doses, month-to-month, compounded) | Not disclosed |
| Semaglutide / yr (modeled) | $2,148 | $3,348 |
| Tirzepatide / yr (modeled) | $3,108 | — |
| Coverage | Coverage not published | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #171 | #177 |
YourEra
62/100Where the value is
- A 6-month prepay drops semaglutide to $99/month, among the lowest compounded-GLP-1 headline prices we track
- No membership-fee structure; the site markets "no hidden fees" and "Same price at every dose"
- Prescriptions are "issued only if deemed medically appropriate" after evaluation by licensed US clinicians, stated plainly
The tradeoffs
- The advertised $99/month requires a 6-month prepay — paying month to month costs $149 for the first month and $179/month after, nearly double the headline
- Tirzepatide's advertised $179 is a first-month intro, not a prepay rung: the page's own words are "Month-to-month intro. Then $259/mo." — so the two molecules' headline discounts work in two different ways on one page
Cost Plus Drugs
64/100Where the value is
- Transparent pricing: wholesale cost + 15% markup + $5 pharmacy fee, the same for everyone
- Around $279/mo for branded Ozempic — well below typical retail list prices
- Mark Cuban's PBM-disrupting pharmacy, praised by Forbes Health, Wired, and KFF Health News
The tradeoffs
- Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
- Ozempic is FDA-indicated for type 2 diabetes, not weight management — weight-loss use is off-label
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.