Head-to-head · Cost-Efficiency Index
Yes Clinic vs Vital Step
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Yes Clinic
Shoppers who can pay for three months at once and want a price that won't rise as their dose goes up.
Visit Yes ClinicVital Step
Shoppers who want a GLP-1 tablet option in any state and are willing to finish the intake to see the real monthly price before paying.
Visit Vital StepThe verdict
Yes Clinic and Vital Step tie on the Cost-Efficiency Index at 65/100, so neither wins outright on the numbers, so choose on fit. Yes Clinic: Shoppers who can pay for three months at once and want a price that won't rise as their dose goes up. Vital Step: Shoppers who want a GLP-1 tablet option in any state and are willing to finish the intake to see the real monthly price before paying.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Yes Clinic.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Yes Clinic | Vital Step |
|---|---|---|
| Cost-Efficiency Index | 65/100 | 65/100 |
| Semaglutide / mo | $129/mo3-month plan, billed $387 upfront, same price at every dose, compounded | $161/moLowest advertised rate, compounded; the plan behind it and the regular monthly price appear only after the intake |
| Tirzepatide / mo | $149/mo3-month plan, billed $447 upfront, same price at every dose, compounded | $198/moLowest advertised rate, compounded; the regular monthly price appears only after the intake |
| Semaglutide / yr (modeled) | $1,548 | $1,932 |
| Tirzepatide / yr (modeled) | $1,788 | $2,376 |
| Coverage | Not published | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #211 | #212 |
Yes Clinic
65/100Where the value is
- Every plan price is on the product pages with no quiz or account: semaglutide $387 for 3 months or $699 for 6, tirzepatide $447 or $894
- The price stays the same at every dose, and the online consultation, shipping and membership are all included at $0
- If a provider declines to prescribe, you aren't charged for medication, and a 6-month plan refunds months 4 to 6 if they aren't approved
The tradeoffs
- There is no single-month plan: the cheapest way in is three months paid upfront
- The homepage says GLP-1 programs start "From $199/month" and mentions monthly plan rates, while the product pages show only $129 and $149 a month on 3- and 6-month plans
Vital Step
65/100Where the value is
- Semaglutide and tirzepatide both come as weekly injections or daily dissolving tablets
- Publishes a list of all 50 states it ships to
- Free expedited delivery and round-the-clock support, with side-effect questions and dose adjustments included
The tradeoffs
- Only "as low as" figures are published; the plan length behind $161 and $198 and the regular month-to-month price are shown only after the intake
- No refunds at all: the refund policy says all fees and charges are non-refundable, in whole or in part
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.