Head-to-head · Cost-Efficiency Index
Tyde Wellness vs Primary Clinic (Direct GLP)
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Tyde Wellness
Shoppers who want a named, LegitScript-certified five-pharmacy compounded-GLP-1 network with no long-term commitment.
Visit Tyde WellnessPrimary Clinic (Direct GLP)
Shoppers inside its 10 served states who want primary care bundled with the prescription and will price the membership in.
Visit Primary Clinic (Direct GLP)The verdict
Tyde Wellness takes it, leading the Cost-Efficiency Index 66 to 65. Tyde Wellness is a compounded-GLP-1 and longevity telehealth platform (weight loss, HRT, hair, longevity) serving all 50 states, with semaglutide starting at $149/mo and tirzepatide at $249/mo. Primary Clinic (Direct GLP) still earns a C — Shoppers inside its 10 served states who want primary care bundled with the prescription and will price the membership in.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Tyde Wellness.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Tyde Wellness | Primary Clinic (Direct GLP) |
|---|---|---|
| Cost-Efficiency Index | 66/100 | 65/100 |
| Semaglutide / mo | $149/mo (microdose tier, starting dose, compounded) | $85/mo (0.25-0.75 mg band, membership required, compounded) |
| Tirzepatide / mo | $249/mo (microdose tier, starting dose, compounded) | $133/mo (1.25-2.5 mg band, membership required, compounded) |
| Semaglutide / yr (modeled) | $1,788 | $1,020 |
| Tirzepatide / yr (modeled) | $2,988 | $1,596 |
| Coverage | All 50 states | WA, NM, AZ, UT, FL, DC, KS, OK, VA, GA |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #143 | #146 |
Tyde Wellness
66/100Where the value is
- All 50 states served, confirmed via the site's own full state list
- Five named 503A pharmacy partners with cities — unusually specific for this market
- LegitScript certified, with a verification badge displayed
The tradeoffs
- No visible per-dose price ladder — the $149/$249 is a 'starting at' figure, and whether a higher titrated dose costs more could not be confirmed without completing the gated intake
- No visit or membership fee is disclosed either way — it's unclear whether $149/$249 is genuinely all-in or medication-only
Primary Clinic (Direct GLP)
65/100Where the value is
- Both molecules are priced, as dose bands, so the cost of titrating up is visible rather than hidden
- The $89 membership buys unlimited primary care, direct text access and same-day appointments, not just a prescription
- Real per-dose pricing rather than one headline rate
The tradeoffs
- The medication price is on top of an $89/mo membership, which the FAQ states does not include the drug — all-in is about $174/mo semaglutide and $222/mo tirzepatide
- Prices are published as dose BANDS, and the cheapest tirzepatide band starts at 1.25 mg, below the 2.5 mg labeled starting dose
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.