Head-to-head · Cost-Efficiency Index
Oxford's Medical Weight Loss (The Calibrate Clinic) vs Fifty 410
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Oxford's Medical Weight Loss (The Calibrate Clinic)
Cost-first shoppers who want a flat, no-contract monthly rate without hunting for hidden membership fees.
Visit Oxford's Medical Weight Loss (The Calibrate Clinic)Fifty 410
Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Visit Fifty 410The verdict
Oxford's Medical Weight Loss (The Calibrate Clinic) takes it, leading the Cost-Efficiency Index 60 to 59. The Calibrate Clinic is a Lafayette, Louisiana-based telehealth weight-loss provider offering phone-only consultations and nationwide shipping for compounded GLP-1 and GLP-1+GIP treatments. Fifty 410 still earns a C — Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Oxford's Medical Weight Loss (The Calibrate Clinic).
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Oxford's Medical Weight Loss (The Calibrate Clinic) | Fifty 410 |
|---|---|---|
| Cost-Efficiency Index | 60/100 | 59/100 |
| Semaglutide / mo | $145/mo (plus a separate fee, compounded) | $199/mo (all doses, compounded) |
| Tirzepatide / mo | $199/mo (compounded) | $133/mo (starting dose, 3-month plan, compounded) |
| Semaglutide / yr (modeled) | $1,740 | $2,388 |
| Tirzepatide / yr (modeled) | $2,388 | $1,596 |
| Coverage | 2 states | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #258 | #263 |
Oxford's Medical Weight Loss (The Calibrate Clinic)
60/100Where the value is
- Advertised $145/mo GLP-1 rate is genuinely 'all-inclusive' — no separate membership or platform fee stacked on top, unlike the $99-149/mo extra the site's own comparison table says competitors charge
- No contracts and no cancellation fees stated anywhere in the pricing copy
- Financing available through CareCredit, Klarna, and Afterpay for patients who want to spread cost
The tradeoffs
- Site names no medical director, no prescribing physicians, and no compounding pharmacy anywhere — a bigger transparency gap than most peers in this batch
- No LegitScript seal or third-party pharmacy certification visible on the site
Full Oxford's Medical Weight Loss (The Calibrate Clinic) review →
Fifty 410
59/100Where the value is
- No recurring subscription — you pay once per order and are not auto-billed
- Transparent per-tier tirzepatide totals ($399/$499/$549) shown alongside the per-month math, so the real charge is visible if you read past the headline
- Free overnight/2-day shipping and refrigerated packaging included in every tier
The tradeoffs
- Tirzepatide's advertised '$133/month' is a 3-month prepay of $399 charged in one transaction, not a monthly recurring price — the cheapest advertised number is not what most shoppers will assume
- Semaglutide has no discounted multi-month tier and, at $199 flat, actually costs more per month than tirzepatide's cheapest bundle
Regulatory note: the FDA issued a warning letter to Aspen Aesthetics dba Fifty 410 in February 2026. We still list and link to Fifty 410; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.