Head-to-head · Cost-Efficiency Index
Strut Health vs Sesame Care
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Strut Health
Anyone optimizing total monthly outlay who will keep an auto-refill running, and anyone whose real objection is the needle.
Visit Strut HealthSesame Care
People who specifically want FDA-approved brand-name medication (including the Wegovy pill or oral Rybelsus) from an established, verified marketplace and will budget for a two-part cost.
Visit Sesame CareThe verdict
Strut Health takes it, leading the Cost-Efficiency Index 87 to 86. $99/month sublingual semaglutide — among the lowest entry costs we track — from one of the very few programs selling the same molecule as a lozenge or an injection at a single price. Sesame Care still earns a B — People who specifically want FDA-approved brand-name medication (including the Wegovy pill or oral Rybelsus) from an established, verified marketplace and will budget for a two-part cost.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Strut Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Strut Health | Sesame Care |
|---|---|---|
| Cost-Efficiency Index | 87/100 | 86/100 |
| Semaglutide / mo | From $99/mo sublingual, $149/mo injectable | $149/mo medication + $59/mo care subscription (that rate needs a 12-month commitment) |
| Tirzepatide / mo | From $199/mo either route | Brand (Zepbound) |
| Semaglutide / yr (modeled) | $1,188 | — |
| Tirzepatide / yr (modeled) | $2,388 | — |
| Coverage | 49 states (not Arkansas) | Nationwide |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Compounded only | Yes |
| Rank here | #5 | #7 |
Strut Health
87/100Where the value is
- $99/mo for sublingual semaglutide is among the lowest disclosed rates we track; tirzepatide is $199 either route
- Sublingual lozenges for both molecules at the same price as the injection
- Free physician visit, free shipping and free follow-up care included rather than billed separately
The tradeoffs
- The $99 and $149 headline figures require auto-refill — a one-off order costs more, so the true cost depends on staying subscribed
- Asynchronous by design: their FAQ notes some states need no phone consultation, so you may never speak to the prescriber
Regulatory note: the FDA issued a warning letter to Strut Health, LLC dba Strut in February 2026. We still list and link to Strut Health; you should know the letter is on the public record before you decide.
Sesame Care
86/100Where the value is
- Widest brand-name formulary we list — Wegovy pen and pill, Zepbound, Ozempic, Mounjaro and oral Rybelsus, all FDA-approved rather than compounded
- Established national marketplace operating since 2018, with LegitScript certification and BBB recognition
- Wegovy pill starts around $149/mo, and oral routes are available for the needle-averse
The tradeoffs
- Two-part cost — $149/mo medication plus a separate care subscription from $59/mo, so the all-in floor is about $208/mo, and the $59 rate itself requires a 12-month commitment
- A generalist telehealth marketplace, not a dedicated GLP-1 program
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.