Head-to-head · Cost-Efficiency Index
StackMD vs Fifty 410
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
StackMD
Shoppers price-scanning for the lowest advertised entry point, who should confirm true dose-adjusted cost before signing up.
Visit StackMDFifty 410
Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Visit Fifty 410The verdict
StackMD takes it, leading the Cost-Efficiency Index 60 to 59. StackMD (stackmdhealth.com) is a telehealth weight-loss and longevity platform advertising both compounded semaglutide and tirzepatide at an identical 'starting at $99/month' headline price with no dose tiers shown -- likely a lowest-dose teaser rather than a representative cost. Fifty 410 still earns a C — Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs StackMD.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | StackMD | Fifty 410 |
|---|---|---|
| Cost-Efficiency Index | 60/100 | 59/100 |
| Semaglutide / mo | Not disclosed | $199/mo (all doses, compounded) |
| Tirzepatide / mo | Not disclosed | $133/mo (starting dose, 3-month plan, compounded) |
| Semaglutide / yr (modeled) | — | $2,388 |
| Tirzepatide / yr (modeled) | — | $1,596 |
| Coverage | All 50 states | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #257 | #263 |
StackMD
60/100Where the value is
- Low advertised entry price ($99/mo) for both semaglutide and tirzepatide
- Clear FDA-compounding disclaimer shown up front
- Distinct national telehealth brand (separate from the similarly-named Long Island clinic)
The tradeoffs
- Identical $99 headline for both drugs strongly suggests a lowest-dose teaser, not full treatment pricing
- No dose tiers, medical director, pharmacy name, states list, or LegitScript status could be confirmed
Fifty 410
59/100Where the value is
- No recurring subscription — you pay once per order and are not auto-billed
- Transparent per-tier tirzepatide totals ($399/$499/$549) shown alongside the per-month math, so the real charge is visible if you read past the headline
- Free overnight/2-day shipping and refrigerated packaging included in every tier
The tradeoffs
- Tirzepatide's advertised '$133/month' is a 3-month prepay of $399 charged in one transaction, not a monthly recurring price — the cheapest advertised number is not what most shoppers will assume
- Semaglutide has no discounted multi-month tier and, at $199 flat, actually costs more per month than tirzepatide's cheapest bundle
Regulatory note: the FDA issued a warning letter to Aspen Aesthetics dba Fifty 410 in February 2026. We still list and link to Fifty 410; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.