Head-to-head · Cost-Efficiency Index
Spry vs Polly
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Spry
Shoppers who want compounded GLP-1 bundled with anti-aging peptides from one named founding team.
Visit SpryPolly
Shoppers who understand the pricing is billed weekly and want a flat, dose-independent recurring charge from a named pharmacy.
Visit PollyThe verdict
Spry takes it, leading the Cost-Efficiency Index 67 to 66. Spry is a weight-loss and anti-aging telehealth brand, founded by Gabriel Mullins, Sara Yoder, and Tyler Bowman. Polly still earns a C — Shoppers who understand the pricing is billed weekly and want a flat, dose-independent recurring charge from a named pharmacy.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Spry.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Spry | Polly |
|---|---|---|
| Cost-Efficiency Index | 67/100 | 66/100 |
| Semaglutide / mo | $199/moAll doses, compounded | $135/week$585/mo equiv. |
| Tirzepatide / mo | $299/moAll doses, compounded | $199/week$862/mo equiv. |
| Semaglutide / yr (modeled) | $2,388 | $7,020 |
| Tirzepatide / yr (modeled) | $3,588 | $10,344 |
| Coverage | Coverage not published | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #174 | #179 |
Spry
67/100Where the value is
- Real, named founding team with individual bios on its About page
- Pricing shown directly on the homepage and product pages, no sign-up wall required
- Explicitly describes its GLP-1s as compounded rather than leaving formulation ambiguous
The tradeoffs
- No dose-tier price breakdown is published for either drug
- The site doesn't name its compounding pharmacy
Polly
66/100Where the value is
- Names two specific 503A partner compounding pharmacies (Hallandale Pharmacy, VialsRx) rather than staying anonymous
- Nationwide all-50 access with flat pricing at every dose
- Displays a LegitScript certification seal
The tradeoffs
- The headline $135/$199 prices are billed WEEKLY, not monthly — the real monthly-equivalent cost is roughly $585 (semaglutide) and $862 (tirzepatide)
- Compounded only — no brand-name or oral route
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.