Head-to-head · Cost-Efficiency Index
SkyRx vs Superpower
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
SkyRx
Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.
Visit SkyRxSuperpower
People who want twice-yearly blood work and a GLP-1 prescription on one account, and who will pay a yearly membership to get both.
Visit SuperpowerThe verdict
SkyRx and Superpower tie on the Cost-Efficiency Index at 55/100, so neither wins outright on the numbers, so choose on fit. SkyRx: Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate. Superpower: People who want twice-yearly blood work and a GLP-1 prescription on one account, and who will pay a yearly membership to get both.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs SkyRx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | SkyRx | Superpower |
|---|---|---|
| Cost-Efficiency Index | 55/100 | 55/100 |
| Semaglutide / mo | $199/moCompounded | $229/moCompounded, members only; the membership is billed separately |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | $2,388 | $2,748 |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | Coverage not published | Not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #396 | #402 |
SkyRx
55/100Where the value is
- Simple, single headline price displayed on the weight-loss page
- Claims LegitScript certification
- Straightforward telehealth intake flow
The tradeoffs
- The '$199/mo' price is a 12-month prepay rate, not a cancel-anytime monthly price -- a major disclosure trap
- Tirzepatide not yet available ('coming soon'), so half the category is unpriced
Superpower
55/100Where the value is
- The semaglutide price, $229 a month, is printed on its product page before you sign up
- The membership includes 150+ lab tests across two blood draws a year, at a Quest location or at home
- A licensed physician on its clinical team reviews your questionnaire, and the plan includes weekly check-ins and dose adjustments
The tradeoffs
- Semaglutide is sold to members only, so the $349 yearly membership sits on top of the $229 monthly medication price
- The site prints two membership prices: $349 a year on the homepage and "$17 per month, billed annually" on the semaglutide page
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.