Head-to-head · Cost-Efficiency Index
SkyRx vs Fierce Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
SkyRx
Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.
Visit SkyRxFierce Health
Shoppers specifically seeking a below-standard 'microdose' GLP-1 protocol at a discounted entry price.
Visit Fierce HealthThe verdict
SkyRx and Fierce Health tie on the Cost-Efficiency Index at 55/100, so neither wins outright on the numbers. For most shoppers we'd start with SkyRx (ranked #346, a hair above #351) — Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate. But Fierce Health is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs SkyRx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | SkyRx | Fierce Health |
|---|---|---|
| Cost-Efficiency Index | 55/100 | 55/100 |
| Semaglutide / mo | $199/mo (compounded) | Not disclosed |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | $2,388 | — |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | Coverage not published | 30 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #346 | #351 |
SkyRx
55/100Where the value is
- Simple, single headline price displayed on the weight-loss page
- Claims LegitScript certification
- Straightforward telehealth intake flow
The tradeoffs
- The '$199/mo' price is a 12-month prepay rate, not a cancel-anytime monthly price -- a major disclosure trap
- Tirzepatide not yet available ('coming soon'), so half the category is unpriced
Fierce Health
55/100Where the value is
- Semaglutide is currently listed at a steep markdown ($197 vs. a stated $591 regular price) if the discount holds at checkout
- Sells both semaglutide and tirzepatide with clearly separated pricing rather than bundling them
- Discloses the standard compounding/FDA disclaimer plainly in the footer
The tradeoffs
- The $591 'regular price' next to a $197 'sale price' is a large, unexplained gap — no page discloses how long the discount lasts or what the price reverts to
- No mg dose amount is disclosed for either 'microdose' product on any page reached
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.