Head-to-head · Cost-Efficiency Index
SkinnyRx vs Navio MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
SkinnyRx
Shoppers who have already decided on a long commitment and want the term priced openly rather than hidden behind an intake — not price-first shoppers comparing on the advertised figure.
Visit SkinnyRxNavio MD
Shoppers who want compounded tirzepatide with a brand-name fallback path on the same platform, 48 states.
Visit Navio MDThe verdict
Navio MD takes it, leading the Cost-Efficiency Index 73 to 71. NavioMD is a 48-state telehealth platform selling compounded tirzepatide from $189/mo plus brand-name Ozempic, Zepbound, and Mounjaro at near-retail 'as low as' prices. SkinnyRx still earns a C — Shoppers who have already decided on a long commitment and want the term priced openly rather than hidden behind an intake — not price-first shoppers comparing on the advertised figure.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Navio MD.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | SkinnyRx | Navio MD |
|---|---|---|
| Cost-Efficiency Index | 71/100 | 73/100 |
| Semaglutide / mo | $349/mo month-to-month ($299 on 4 months, $249 on 6, $199 only on 12) | $345/mo (brand Ozempic) |
| Tirzepatide / mo | $399/mo month-to-month ($349 on 4 months, $329 on 6, $299 only on 12) | $189/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $4,188 | $4,140 |
| Tirzepatide / yr (modeled) | $4,788 | $2,268 |
| Coverage | Most states | 48 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #66 | #69 |
SkinnyRx
71/100Where the value is
- A complete four-term ladder for both molecules is published rather than gated, so the cost of not committing is knowable before signup
- Both compounded molecules are offered, with the same term structure on each
- The twelve-month rate is genuinely low for the category if a year is a commitment you were going to make anyway
The tradeoffs
- The '$199/month' it advertises everywhere is the TWELVE-MONTH rung. The rate you can stop after a month is $349 — 75% higher — and the figure appears without that term attached
- An FDA warning letter is on public record against Lean Rx, Inc. dba SkinnyRx, issued 20 February 2026. We disclose it and we do not treat it as disqualifying
Regulatory note: the FDA issued a warning letter to Lean Rx, Inc. dba SkinnyRx in February 2026. We still list and link to SkinnyRx; you should know the letter is on the public record before you decide.
Navio MD
73/100Where the value is
- LegitScript certified with board-certified providers claimed
- Both compounded and brand-name options on one platform
- 48-state coverage with the two exclusions (AL, MS) explicitly disclosed rather than hidden
The tradeoffs
- No compounded semaglutide offered — only brand-name Ozempic for that molecule, at a much higher price than compounded competitors
- All prices are 'as low as' floors; the exact dose tied to each starting price is not published
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.