Head-to-head · Cost-Efficiency Index
SkinnyRx vs Clume Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
SkinnyRx
Shoppers who have already decided on a long commitment and want the term priced openly rather than hidden behind an intake — not price-first shoppers comparing on the advertised figure.
Visit SkinnyRxClume Health
Readers who want the dispensing pharmacies named up front and do not need the price broken out by molecule.
Visit Clume HealthThe verdict
Clume Health takes it, leading the Cost-Efficiency Index 73 to 71. Clume Health charges one $259 monthly price for its Signature program whichever GLP-1 a provider picks and whichever route you take, names its four dispensing pharmacies with addresses, and advertises a $199 figure that matches nothing it sells. SkinnyRx still earns a C — Shoppers who have already decided on a long commitment and want the term priced openly rather than hidden behind an intake — not price-first shoppers comparing on the advertised figure.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Clume Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | SkinnyRx | Clume Health |
|---|---|---|
| Cost-Efficiency Index | 71/100 | 73/100 |
| Semaglutide / mo | $349/mo month-to-month ($299 on 4 months, $249 on 6, $199 only on 12) | $259/month month-to-month (one Signature price covers semaglutide or tirzepatide, oral or injectable; $186/mo needs a 52-week plan) |
| Tirzepatide / mo | $399/mo month-to-month ($349 on 4 months, $329 on 6, $299 only on 12) | $259/month month-to-month (the same Signature price; $186/mo needs a 52-week plan) |
| Semaglutide / yr (modeled) | $4,188 | $3,108 |
| Tirzepatide / yr (modeled) | $4,788 | $3,108 |
| Coverage | Most states | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #60 | #66 |
SkinnyRx
71/100Where the value is
- A complete four-term ladder for both molecules is published rather than gated, so the cost of not committing is knowable before signup
- Both compounded molecules are offered, with the same term structure on each
- The twelve-month rate is genuinely low for the category if a year is a commitment you were going to make anyway
The tradeoffs
- The '$199/month' it advertises everywhere is the TWELVE-MONTH rung. The rate you can stop after a month is $349 — 75% higher — and the figure appears without that term attached
- An FDA warning letter is on public record against Lean Rx, Inc. dba SkinnyRx, issued 20 February 2026. We disclose it and we do not treat it as disqualifying
Regulatory note: the FDA issued a warning letter to Lean Rx, Inc. dba SkinnyRx in February 2026. We still list and link to SkinnyRx; you should know the letter is on the public record before you decide.
Clume Health
73/100Where the value is
- Names all four dispensing pharmacies with street addresses, phone numbers and websites, so a buyer can look up who actually compounds the prescription
- The price is published before the intake and covers the consultation, ongoing oversight, the medication and delivery
- One figure covers semaglutide, tirzepatide, oral and injectable, so switching molecule or route does not change the bill
The tradeoffs
- Both headline prices on the homepage match nothing on sale: "*$199/month" against real floors of $259 and $219, and "*$159/month" against $216 — and neither asterisk resolves to a footnote
- The cheaper monthly figures are commitments rather than rates: $186 a month requires a 52-week plan and $200 a month a 12-week one
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.