Sipra vs Rx.com

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Sipra

Provider comparison

Shoppers ready to commit to at least three months who want a price that doesn't rise with the dose and a full price table before they start.

Semaglutide / month: $189/mo3-month plan, $567 charged up front, same price at every dose, compounded
Tirzepatide / month: $249/mo3-month plan, $747 charged up front, same price at every dose, compounded

Index 78/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Sipra pricing Read review

Rx.com

Provider comparison

Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.

Semaglutide / month: $175/moMonth-to-month; $165 on three months, $146 on six and $99 on twelve, prepaid
Tirzepatide / month: $285/moMonth-to-month; $265 on three months, $259 on six and $149 on twelve, prepaid

Index 77/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Rx.com pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Sipra has the higher Cost-Efficiency Index: 78/100 versus 77/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

Sipra: All 50 states
Rx.com: 47 states on its program page; product pages say 49

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Sipra

Rx.com

Semaglutide / month: Sipra: $189/mo3-month plan, $567 charged up front, same price at every dose, compounded; Rx.com: $175/moMonth-to-month; $165 on three months, $146 on six and $99 on twelve, prepaid

Tirzepatide / month: Sipra: $249/mo3-month plan, $747 charged up front, same price at every dose, compounded; Rx.com: $285/moMonth-to-month; $265 on three months, $259 on six and $149 on twelve, prepaid

Semaglutide / year (modeled): Sipra: $2,268; Rx.com: $2,100

Tirzepatide / year (modeled): Sipra: $2,988; Rx.com: $3,420

State availability: Sipra: All 50 states; Rx.com: 47 states on its program page; product pages say 49

Oral / sublingual option listed: Sipra: Yes; Rx.com: Not listed

Brand-name access listed: Sipra: Not confirmed; Rx.com: Not confirmed

Provider facts checked: Sipra: October 2026; Rx.com: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Sipra

Shoppers ready to commit to at least three months who want a price that doesn't rise with the dose and a full price table before they start.

Reasons to consider it

A full price table by drug and plan length is published, and the price stays the same as your dose goes up
Your card isn't charged until a licensed physician reviews and approves your treatment
Injections, lower-dose microdose injections and dissolving tablets are all offered for both drugs

What to weigh up

There's no month-to-month option for GLP-1s: the shortest plan is three months, charged in one payment ($567 for semaglutide, $747 for tirzepatide)
To stop the next order you have to cancel at least 13 days before your paid period ends
Leaving a 6- or 12-month plan early is settled under the terms rather than refunded in full

Compounded drugs are not FDA-approved. Understand the medication options.

Check Sipra pricing Read the full Sipra review

Rx.com

Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.

Reasons to consider it

"No automatic renewals" is printed under the plan card itself rather than buried in the terms
Names Manifest Pharmacy in Greer, South Carolina with a full street address, and MD Integrations as the provider network, on the same page as the price
One flat price at every dose from 2.5 mg to 15 mg, with the provider visit, injection supplies and cold shipping stated as included

What to weigh up

The $99/mo semaglutide and $149/mo tirzepatide headlines require a 12-month prepayment of $1,188 or $1,788
Its program page excludes Alaska, Louisiana and Mississippi, while product pages exclude only Alaska; confirm coverage before paying
Injection only — no oral route and no brand-name lane

Compounded drugs are not FDA-approved. Understand the medication options.

Check Rx.com pricing Read the full Rx.com review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

SipraRx.com

Normalized Cost/Month: Sipra:
64/100; Rx.com:
74/100

Price Transparency: Sipra:
97/100; Rx.com:
76/100

Nationwide Access: Sipra:
86/100; Rx.com:
82/100

Formulation Options: Sipra:
77/100; Rx.com:
62/100

Clinical Oversight: Sipra:
78/100; Rx.com:
78/100

Contract Flexibility: Sipra:
61/100; Rx.com:
96/100

Before you sign up

Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.