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WeighLab

Signos vs Tru2u

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Signos

Provider comparison

Shoppers who want glucose-monitor data paired with a GLP-1 prescription in one program, and who can accept a 3- or 6-month term.

Semaglutide / month
$199/moStarting price, 3- or 6-month GLP-1 + CGM plan, compounded
Tirzepatide / month
Not disclosed
Index 62/100 · Grade CChecked October 2026

Tru2u

Provider comparison

Shoppers comparing a listed catalog price who understand fulfillment happens through a separate, unnamed telehealth partner.

Semaglutide / month
$225/moCompounded
Tirzepatide / month
$345/moCompounded
Index 61/100 · Grade CChecked October 2026

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Signos has the higher Cost-Efficiency Index: 62/100 versus 61/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

Signos
All 50 states
Tru2u
Coverage not published

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Signos

Tru2u

Semaglutide / month
Signos: $199/moStarting price, 3- or 6-month GLP-1 + CGM plan, compounded
Tru2u: $225/moCompounded
Tirzepatide / month
Signos: Not disclosed
Tru2u: $345/moCompounded
Semaglutide / year (modeled)
Signos: $2,388
Tru2u: $2,700
Tirzepatide / year (modeled)
Signos: —
Tru2u: $4,140
State availability
Signos: All 50 states
Tru2u: Coverage not published
Oral / sublingual option listed
Signos: Not listed
Tru2u: Yes
Brand-name access listed
Signos: Not confirmed
Tru2u: Not confirmed
Provider facts checked
Signos: October 2026
Tru2u: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Signos

Shoppers who want glucose-monitor data paired with a GLP-1 prescription in one program, and who can accept a 3- or 6-month term.

Reasons to consider it

  • The Signos+ plan bundles a GLP-1 prescription with the glucose monitor and app from $199 a month
  • The terms name the four pharmacies that fill prescriptions
  • Offered in all 50 states plus D.C.

What to weigh up

  • The $199 price is for a 3- or 6-month plan, not month to month
  • The site's own FAQ says Signos doesn't offer prescription medication, which contradicts the GLP-1 plan
  • The plan doesn't say which GLP-1 you'd get, and no tirzepatide price is shown

Tru2u

Shoppers comparing a listed catalog price who understand fulfillment happens through a separate, unnamed telehealth partner.

Reasons to consider it

  • Offers a combined semaglutide+tirzepatide injection (GLP Squared, $275) that most programs we track don't, priced below standalone tirzepatide
  • Both injectable and oral-tablet forms listed for semaglutide and tirzepatide at matching prices
  • Transparent upfront catalog pricing with free shipping stated on product pages

What to weigh up

  • Each GLP-1 product page still says it's for 'qualified healthcare professionals and practitioners', while the FAQ describes an ordinary patient path (quiz, provider review, partner pharmacy), so ask support which applies to you before starting
  • No compounding pharmacy is named, and no LegitScript badge is shown
  • No dose or supply length (week or month) is listed next to any price, so ask what $225/$345/$275 actually buys

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

SignosTru2u
Normalized Cost/Month
Signos:
39/100
Tru2u:
58/100
Price Transparency
Signos:
84/100
Tru2u:
86/100
Nationwide Access
Signos:
86/100
Tru2u:
24/100
Formulation Options
Signos:
53/100
Tru2u:
77/100
Clinical Oversight
Signos:
84/100
Tru2u:
68/100
Contract Flexibility
Signos:
20/100
Tru2u:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

Keep comparing

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.