Head-to-head · Cost-Efficiency Index
Signos vs Genesis Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Signos
Cost-first shoppers who want glucose-monitoring data paired with a GLP-1 prescription in one program, if a 3- or 6-month term is acceptable.
Visit SignosGenesis Health
Shoppers comparing multi-category telehealth (weight loss + sexual health + anti-aging) willing to prepay or finance to unlock the lowest listed rate.
Visit Genesis HealthThe verdict
Signos takes it, leading the Cost-Efficiency Index 44 to 43. Signos is a CGM-first metabolic-health company whose Signos+ plan genuinely bundles clinician-prescribed compounded semaglutide with its FDA-cleared continuous glucose monitor and coaching app. Genesis Health still earns a C — Shoppers comparing multi-category telehealth (weight loss + sexual health + anti-aging) willing to prepay or finance to unlock the lowest listed rate.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Signos.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Signos | Genesis Health |
|---|---|---|
| Cost-Efficiency Index | 44/100 | 43/100 |
| Semaglutide / mo | $199/mo (starting dose, bundle, plus a separate fee, compounded) | Not disclosed |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | $2,388 | — |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #486 | #489 |
Signos
44/100Where the value is
- Confirmed as a genuine GLP-1 prescriber, not CGM-only — the Signos+ plan bundles compounded semaglutide with the CGM, verified against the separate $127/mo CGM-only price
- Starting price of $199/month is stated to include both the medication program and the CGM hardware/app
- FDA-cleared CGM hardware paired with an AI-powered coaching app for ongoing glucose-guided tracking
The tradeoffs
- The headline $199/month is a 3- or 6-month PROGRAM rate, not a plain month-to-month subscription, and the page doesn't disclose what happens after the term ends
- Only semaglutide is shown in the bundled program; tirzepatide availability is not confirmed anywhere accessible
Genesis Health
43/100Where the value is
- Offers both compounded and FDA-approved branded GLP-1 options (Ozempic, Wegovy, Zepbound) in one place
- Buy-now-pay-later financing available for those who can't pay a lump sum upfront
- Multi-category platform (weight loss, sexual health, anti-aging) for one-stop telehealth shopping
The tradeoffs
- Headline '$176/mo' price is explicitly a 2-month-prepay-or-financed rate, not a real month-to-month price
- No medical director, compounding pharmacy, or state-coverage list disclosed
Regulatory note: the FDA issued a warning letter to Genesis Health International Inc. dba Genesis in February 2026. We still list and link to Genesis Health; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.