Head-to-head · Cost-Efficiency Index
ShedRx (Shed) vs NewSelf
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
ShedRx (Shed)
People who want a needle-free route or a brand-name option, and who will commit to twelve months to reach the lowest price.
Visit ShedRx (Shed)NewSelf
Budget shoppers who want a verified all-50 program and one of the lowest disclosed tirzepatide prices in the value tier.
Visit NewSelfThe verdict
ShedRx (Shed) and NewSelf tie on the Cost-Efficiency Index at 87/100, so neither wins outright on the numbers. For most shoppers we'd start with ShedRx (Shed) (ranked #4, a hair above #11) — People who want a needle-free route or a brand-name option, and who will commit to twelve months to reach the lowest price. But NewSelf is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs ShedRx (Shed).
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | ShedRx (Shed) | NewSelf |
|---|---|---|
| Cost-Efficiency Index | 87/100 | 87/100 |
| Semaglutide / mo | $199/mo ($159 on a 12-month plan) | $100/mo |
| Tirzepatide / mo | $299/mo ($239 on a 12-month plan) | $144/mo |
| Semaglutide / yr (modeled) | $2,388 | $1,200 |
| Tirzepatide / yr (modeled) | $3,588 | $1,728 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #4 | #11 |
ShedRx (Shed)
87/100Where the value is
- Four routes to a GLP-1 — injection, liquid drops, lozenges and a daily oral pill
- Brand Zepbound and Wegovy available alongside the compounded line
- Available in all 50 states, with health coaching included and a published 120-day weight-loss guarantee
The tradeoffs
- The advertised "as low as" prices ($159 semaglutide, $239 tirzepatide) require a TWELVE-MONTH commitment — month-to-month is $199 and $299
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
NewSelf
87/100Where the value is
- $100 semaglutide / $144 tirzepatide — one of the cheapest verified combined prices in the ranking
- Nationwide all-50 coverage with both molecules published up front
- LegitScript-certified pharmacy behind the low price
The tradeoffs
- Compounded only — no brand-name or oral option
- Newer consumer brand with a thin public track record
Regulatory note: the FDA issued a warning letter to NewSelf Limited dba NewSelf in February 2026. We still list and link to NewSelf; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.