Head-to-head · Cost-Efficiency Index
ShedRx (Shed) vs Enhance MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
ShedRx (Shed)
People who want a needle-free route or a brand-name option, and who will commit to twelve months to reach the lowest price.
Visit ShedRx (Shed)Enhance MD
Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Visit Enhance MDThe verdict
ShedRx (Shed) takes it, leading the Cost-Efficiency Index 87 to 75. The widest set of formats on the board — injection, drops, lozenges and a daily oral pill, plus a real brand Zepbound route — though its cheapest advertised rates need a year-long commitment. Enhance MD still earns a C — Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the board). See how it stacks up: CoreAge Rx vs ShedRx (Shed).
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | ShedRx (Shed) | Enhance MD |
|---|---|---|
| Cost-Efficiency Index | 87/100 | 75/100 |
| Semaglutide / mo | $199/mo ($159 on a 12-month plan) | $212/mo (first month $112) |
| Tirzepatide / mo | $299/mo ($239 on a 12-month plan) | $280/mo (first month $180) |
| Semaglutide / yr (modeled) | $2,388 | $2,544 |
| Tirzepatide / yr (modeled) | $3,588 | $3,360 |
| Coverage | All 50 states | Not disclosed |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank on the board | #3 | #36 |
ShedRx (Shed)
87/100Where the value is
- Four routes to a GLP-1 — injection, liquid drops, lozenges and a daily oral pill
- Brand Zepbound and Wegovy available alongside the compounded line
- Available in all 50 states, with health coaching included and a published 120-day weight-loss guarantee
The tradeoffs
- The advertised "as low as" prices ($159 semaglutide, $239 tirzepatide) require a TWELVE-MONTH commitment — month-to-month is $199 and $299
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
Enhance MD
75/100Where the value is
- Fully published, dose-flat tiered pricing — sema $212/mo, tirz $280/mo, microdose $169/mo, sema+tirz combo $322/mo — no quiz or quote wall
- The rate does not climb as your dose is titrated up, unlike per-mg pricing elsewhere on this board
- Routine lab work at the 6-month mark plus ongoing provider messaging is bundled into the price, not sold separately
The tradeoffs
- Compounded only — no FDA-approved brand-name route (no Wegovy, Ozempic, Mounjaro or Zepbound)
- No oral or sublingual GLP-1 option (injection only)
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.