Head-to-head · Cost-Efficiency Index
Ryze Rx vs VivioMD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Ryze Rx
Cost-first shoppers who want compounded GLP-1s plus a broad TRT and peptide menu on one platform.
Visit Ryze RxVivioMD
Shoppers who want both compounded and FDA-approved GLP-1 options from one nationwide platform, and don't mind completing an intake before seeing price.
Visit VivioMDThe verdict
Ryze Rx takes it, leading the Cost-Efficiency Index 54 to 53. Ryze Rx is a prescription telehealth platform for weight loss, TRT and peptide therapy, prescribing through board-certified physicians and shipping from US-licensed compounding pharmacies. VivioMD still earns a C — Shoppers who want both compounded and FDA-approved GLP-1 options from one nationwide platform, and don't mind completing an intake before seeing price.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Ryze Rx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Ryze Rx | VivioMD |
|---|---|---|
| Cost-Efficiency Index | 54/100 | 53/100 |
| Semaglutide / mo | $199/mo (starting dose, 3 month plan, compounded) | Not disclosed |
| Tirzepatide / mo | $199/mo (starting dose, 3 month plan, compounded) | Not disclosed |
| Semaglutide / yr (modeled) | $2,388 | — |
| Tirzepatide / yr (modeled) | $2,388 | — |
| Coverage | Coverage not published | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #364 | #369 |
Ryze Rx
54/100Where the value is
- Compounded semaglutide and tirzepatide both $199/mo, with $499/$799 three-month bundles
- Physician consultation, ongoing clinical support and discreet shipping included with each prescription
- Broad catalog beyond GLP-1: TRT plus peptides (BPC-157, sermorelin, NAD+, retatrutide and more)
The tradeoffs
- Terms, Privacy Policy and HIPAA notice are dead links - no legal entity, refund policy or governing law disclosed
- Pharmacy partners not named - only 'US-licensed compounding pharmacies'
VivioMD
53/100Where the value is
- Offers both compounded AND FDA-approved branded GLP-1s (Ozempic, Zepbound) -- more flexibility than compounded-only competitors
- Four named pharmacy partners disclosed by name, more transparency than most peers
- Broad state coverage -- 49 states, only Louisiana excluded
The tradeoffs
- No pricing whatsoever is published -- every price is gated behind a full intake assessment
- No medical director name disclosed anywhere on the accessible pages
Regulatory note: the FDA issued a warning letter to VivioMD Group LLC dba VivioMD in June 2026. We still list and link to VivioMD; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.