Head-to-head · Cost-Efficiency Index
Rylo Health vs The Edit
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Rylo Health
Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.
Visit Rylo HealthThe Edit
Shoppers who want one price at every dose and a named pharmacy and medical director, and who may prepay for six months to lower the cost.
Visit The EditThe verdict
Rylo Health and The Edit tie on the Cost-Efficiency Index at 75/100, so neither wins outright on the numbers, so choose on fit. Rylo Health: Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases. The Edit: Shoppers who want one price at every dose and a named pharmacy and medical director, and who may prepay for six months to lower the cost.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Rylo Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Rylo Health | The Edit |
|---|---|---|
| Cost-Efficiency Index | 75/100 | 75/100 |
| Semaglutide / mo | $149/moAll doses, promotional rate, compounded | $259/moCompounded, month to month; same price at every dose |
| Tirzepatide / mo | $249/moAll doses, compounded | $349/moCompounded, month to month; same price at every dose |
| Semaglutide / yr (modeled) | $1,788 | $3,108 |
| Tirzepatide / yr (modeled) | $2,988 | $4,188 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #68 | #71 |
Rylo Health
75/100Where the value is
- Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
- Medication, provider review and shipping are all stated as included in the quoted price, with no add-ons listed
- Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous
The tradeoffs
- The '$100/$160 First 20 rate' shown prominently on the homepage is limited to the first 20 signups only — most shoppers will pay the higher $149/$249 standard rate, and the promo framing can make the real price look lower than it is
- The 'quarterly $349/$499' option doesn't say whether it's one charge or a monthly bill with a commitment, so ask before you choose it
The Edit
75/100Where the value is
- Same price at every dose, with no membership fee and month-to-month plans you can cancel any time
- Three- and six-month plans are labeled as single up-front charges: semaglutide $575 and $1,065, tirzepatide $855 and $1,575
- Names its pharmacy, The Pharmacy Hub, and a board-certified family-medicine medical director
The tradeoffs
- The first-month prices of $200 and $300 are a limited-time offer; the standing rates are $259 and $349
- Paid billing periods aren't pro-rated or refunded, and compounded medication is non-refundable once dispensed
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.