Head-to-head · Cost-Efficiency Index
Rylo Health vs ReflexMD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Rylo Health
Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.
Visit Rylo HealthReflexMD
Shoppers who want one flat monthly price that won't rise with the dose and who are comfortable canceling by phone.
Visit ReflexMDThe verdict
Rylo Health and ReflexMD tie on the Cost-Efficiency Index at 75/100, so neither wins outright on the numbers, so choose on fit. Rylo Health: Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases. ReflexMD: Shoppers who want one flat monthly price that won't rise with the dose and who are comfortable canceling by phone.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Rylo Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Rylo Health | ReflexMD |
|---|---|---|
| Cost-Efficiency Index | 75/100 | 75/100 |
| Semaglutide / mo | $149/moAll doses, promotional rate, compounded | $297/moCompounded, same price at every dose, month to month |
| Tirzepatide / mo | $249/moAll doses, compounded | $367/moCompounded, same price at every dose, month to month |
| Semaglutide / yr (modeled) | $1,788 | $3,564 |
| Tirzepatide / yr (modeled) | $2,988 | $4,404 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #68 | #69 |
Rylo Health
75/100Where the value is
- Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
- Medication, provider review and shipping are all stated as included in the quoted price, with no add-ons listed
- Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous
The tradeoffs
- The '$100/$160 First 20 rate' shown prominently on the homepage is limited to the first 20 signups only — most shoppers will pay the higher $149/$249 standard rate, and the promo framing can make the real price look lower than it is
- The 'quarterly $349/$499' option doesn't say whether it's one charge or a monthly bill with a commitment, so ask before you choose it
ReflexMD
75/100Where the value is
- Both prices are shown on the homepage before any quiz, and the site calls them flat-rate pricing
- The online consultation fee is included in the subscription, and shipping is free and overnight once the pharmacy ships
- Month to month with no long-term contract; 3- and 6-month plans are optional, with 15% off 3-month plans under a current promo code
The tradeoffs
- Outside California you must call to cancel, at least two days before the renewal date; California residents can also cancel by email
- Fees already paid are not refunded once the month is billed
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.