Head-to-head · Cost-Efficiency Index
Rylo Health vs Pillar Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Rylo Health
Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.
Visit Rylo HealthPillar Health
Shoppers who want one flat monthly price for compounded semaglutide or tirzepatide that won't rise as the dose goes up.
Visit Pillar HealthThe verdict
Rylo Health and Pillar Health tie on the Cost-Efficiency Index at 75/100, so neither wins outright on the numbers, so choose on fit. Rylo Health: Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases. Pillar Health: Shoppers who want one flat monthly price for compounded semaglutide or tirzepatide that won't rise as the dose goes up.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Rylo Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Rylo Health | Pillar Health |
|---|---|---|
| Cost-Efficiency Index | 75/100 | 75/100 |
| Semaglutide / mo | $149/moAll doses, promotional rate, compounded | $189/moCompounded, same price at every dose; first month $94.50 with the welcome code |
| Tirzepatide / mo | $249/moAll doses, compounded | $249/moCompounded, same price at every dose; first month $124.50 with the welcome code |
| Semaglutide / yr (modeled) | $1,788 | $2,268 |
| Tirzepatide / yr (modeled) | $2,988 | $2,988 |
| Coverage | All 50 states | 48 states + DC |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #68 | #70 |
Rylo Health
75/100Where the value is
- Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
- Medication, provider review and shipping are all stated as included in the quoted price, with no add-ons listed
- Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous
The tradeoffs
- The '$100/$160 First 20 rate' shown prominently on the homepage is limited to the first 20 signups only — most shoppers will pay the higher $149/$249 standard rate, and the promo framing can make the real price look lower than it is
- The 'quarterly $349/$499' option doesn't say whether it's one charge or a monthly bill with a commitment, so ask before you choose it
Pillar Health
75/100Where the value is
- Both monthly prices are on the weight-loss and product pages before any questionnaire, with $0 membership and free shipping
- The program price covers every dose in the titration ladder, from 0.25 mg to 2.4 mg of semaglutide and 2.5 mg to 15 mg of tirzepatide
- Publishes where it serves: 48 states and Washington, D.C., with Alaska and Mississippi excluded
The tradeoffs
- Pillar is a storefront: starting treatment hands you to a separate checkout platform whose own terms set the charges, renewals, cancellations and refunds
- Its refund policy points you to that provider's terms rather than stating its own cancellation or refund rules
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.