Head-to-head · Cost-Efficiency Index
Rylo Health vs Peter MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Rylo Health
Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.
Visit Rylo HealthPeter MD
Someone who wants a single telehealth account to also cover TRT, hair loss, ED or NAD+ alongside a GLP-1 script, and who will read past the first-month price before budgeting the ongoing cost.
Visit Peter MDThe verdict
Rylo Health takes it, leading the Cost-Efficiency Index 75 to 72. Rylo Health is a compounded GLP-1/NAD+/peptide telehealth platform operating in all 50 states through Lone Star Virtual Health PLLC and dispensing via VialsRX in Houston, TX. Peter MD still earns a C — Someone who wants a single telehealth account to also cover TRT, hair loss, ED or NAD+ alongside a GLP-1 script, and who will read past the first-month price before budgeting the ongoing cost.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Rylo Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Rylo Health | Peter MD |
|---|---|---|
| Cost-Efficiency Index | 75/100 | 72/100 |
| Semaglutide / mo | $149/mo (all doses, promotional rate, compounded) | $149/mo first-time (Level 1), $139/mo returning (Level 2) |
| Tirzepatide / mo | $249/mo (all doses, compounded) | $149 first month, then $249/mo billed quarterly |
| Semaglutide / yr (modeled) | $1,788 | $1,788 |
| Tirzepatide / yr (modeled) | $2,988 | $2,988 |
| Coverage | All 50 states | Varies by treatment — excluded in several states (marketing pages list AL/ID; the affiliate program's own disclosure is wider) |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #52 | #54 |
Rylo Health
75/100Where the value is
- Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
- Medication, provider review, and shipping all stated as included in the quoted price with no add-ons found
- Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous
The tradeoffs
- The '$100/$160 First 20 rate' shown prominently on the homepage is limited to the first 20 signups only — most shoppers will pay the higher $149/$249 standard rate, and the promo framing can make the real price look lower than it is
- The advertised 'quarterly $349/$499' option's actual billing mechanics (one-time total vs. recurring monthly-under-commitment) could not be verified — the product pages that would clarify this render via JavaScript and returned no readable pricing text
Peter MD
72/100Where the value is
- Broadest cross-category catalog in this ranking under one account: TRT, ED, non-GLP-1 weight loss, GLP-1 (semaglutide/tirzepatide), men's hair loss and NAD+, plus sermorelin
- Physician-prescribed, nationwide telehealth brand operating since 2021 (Miami, FL HQ)
- Sermorelin ($585 for a 12-week supply, ~$195/mo) and NAD+ ($369 for an 8-10 week supply, ~$147-184/mo) sit in the same catalog as the GLP-1 line for anyone consolidating multiple scripts
The tradeoffs
- Tirzepatide's $149 first-month rate steps up to $249/mo billed quarterly — the number that matters for budgeting is the renewal price, not the headline
- Semaglutide pricing depends on tier: $149/mo first-time (Level 1) vs $139/mo returning (Level 2), with different total costs ($447 vs $834) over different supply windows, so the all-in cost is not a single number
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.