Head-to-head · Cost-Efficiency Index
RxSpan MD vs Yucca Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
RxSpan MD
Someone who wants to compare a compounded route against brand-name Zepbound or Wegovy without leaving one provider, and who will read past the twelve-month figure.
Visit RxSpan MDYucca Health
Shoppers who want a flat monthly price that won't rise as the dose goes up, with the option to pause instead of cancel.
Visit Yucca HealthThe verdict
RxSpan MD and Yucca Health tie on the Cost-Efficiency Index at 83/100, so neither wins outright on the numbers, so choose on fit. RxSpan MD: Someone who wants to compare a compounded route against brand-name Zepbound or Wegovy without leaving one provider, and who will read past the twelve-month figure. Yucca Health: Shoppers who want a flat monthly price that won't rise as the dose goes up, with the option to pause instead of cancel.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs RxSpan MD.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | RxSpan MD | Yucca Health |
|---|---|---|
| Cost-Efficiency Index | 83/100 | 83/100 |
| Semaglutide / mo | $249/moMonth-to-month for the injection; $219 on three months, $199 on six and $194 on twelve | $146/moMonth to month, same price at every dose, compounded |
| Tirzepatide / mo | $329/moMonth-to-month for the injection; $309 on three months, $289 on six and $269 on twelve | $258/moMonth to month, same price at every dose, compounded |
| Semaglutide / yr (modeled) | $2,988 | $1,752 |
| Tirzepatide / yr (modeled) | $3,948 | $3,096 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #17 | #23 |
RxSpan MD
83/100Where the value is
- Every product and every term carries a published price, including the brand-name lane: Zepbound at $1,069, Ozempic at $1,299 and Wegovy at $1,349
- Three ways to take it on one account: a weekly injection, a daily capsule of either molecule, or a brand-name drug
- Names its medical group, Lion MD, with two lead physicians and their NPI numbers, and lists four dispensing pharmacies with phone numbers
The tradeoffs
- The figure a reader is most likely to meet elsewhere, around $194, is the twelve-month per-month rate; one month of the semaglutide injection is $249
- Its semaglutide prices match Prime Doctor RX's to the dollar at every plan length, so comparing the two on price tells you little
Yucca Health
83/100Where the value is
- Each product page shows all three plans: semaglutide is $146 month to month, $140 a month on three months ($420) and $125 on six ($750); tirzepatide is $258, $248 ($744) and $225 ($1,350)
- The price is locked at every dose for as long as your plan stays active, and pausing keeps the lock
- A written six-month promise refunds everything you paid, including medication, if you follow the plan for six months and haven't lost weight from your logged starting weight
The tradeoffs
- The "$125/mo for life" banner is the six-month plan, billed $750 up front; the no-commitment monthly price is $146
- Once a clinician issues your prescription that order is final and can't be refunded, and you must cancel at least 7 days before a renewal to stop it
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.