Head-to-head · Cost-Efficiency Index
Rx.com vs TrimRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Rx.com
Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.
Visit Rx.comTrimRx
Shoppers who want one monthly package that covers the visit, the medication and shipping, and who will confirm the renewal price at checkout.
Visit TrimRxThe verdict
Rx.com and TrimRx tie on the Cost-Efficiency Index at 77/100, so neither wins outright on the numbers, so choose on fit. Rx.com: Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker. TrimRx: Shoppers who want one monthly package that covers the visit, the medication and shipping, and who will confirm the renewal price at checkout.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Rx.com.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Rx.com | TrimRx |
|---|---|---|
| Cost-Efficiency Index | 77/100 | 77/100 |
| Semaglutide / mo | $175/moMonth-to-month; $165 on three months and $146 on six | $299/moMonth-to-month refill price; first month $199, compounded |
| Tirzepatide / mo | $285/moMonth-to-month; $265 on three months and $259 on six | $399/moMonth-to-month refill price; first month $349, compounded |
| Semaglutide / yr (modeled) | $2,100 | $3,588 |
| Tirzepatide / yr (modeled) | $3,420 | $4,788 |
| Coverage | 49 states on its plan page; its own banner says all 50 | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #55 | #56 |
Rx.com
77/100Where the value is
- "No automatic renewals" is printed under the plan card itself rather than buried in the terms
- Names Manifest Pharmacy in Greer, South Carolina with a full street address, and MD Integrations as the provider network, on the same page as the price
- One flat price at every dose from 2.5 mg to 15 mg, with the provider visit, injection supplies and cold shipping stated as included
The tradeoffs
- The advertised "$146/mo FOR LIFE" is a six-month prepay on semaglutide; month-to-month tirzepatide is $285
- The plan page says 49 states served while the banner on the same site says all 50
TrimRx
77/100Where the value is
- Each monthly package includes the telehealth consultation, the prescription, the medication and shipping, with no separate membership fee listed
- The homepage promises the price stays the same as your dose goes up, and offers to keep your current dose if you switch from another program
- Serves all 50 states, and the terms say so plainly
The tradeoffs
- The homepage says "Starting at $179" and "$259", but the terms list $199 and $349 for the first month and $299 and $399 for each follow-up month, so confirm which price applies to you before paying
- Once your prescription is sent to the pharmacy that month's order can't be refunded; refunds on prepaid multi-month plans must be requested within 28 days of payment
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.