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WeighLab

PlexusDx vs Trillium Meds

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

PlexusDx

Provider comparison

Shoppers who want one price at every dose, an oral option for either molecule, and all 50 states.

Semaglutide / month
$189/moSame price at every dose, month to month, compounded, all-inclusive; $169/mo on a 3-month plan, $149/mo on a 6-month plan
Tirzepatide / month
$289/moSame price at every dose, month to month, compounded, all-inclusive; $269/mo on a 3-month plan, $249/mo on a 6-month plan
Index 79/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check PlexusDx pricing Read review

Trillium Meds

Provider comparison

Shoppers who want compounded GLP-1 in all 50 states with a real month-to-month option and a cheaper 3-month prepay.

Semaglutide / month
$159/moAll doses, compounded
Tirzepatide / month
$199/moAny dose, compounded; pharmacy-specific plans
Index 78/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Trillium Meds pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

PlexusDx has the higher Cost-Efficiency Index: 79/100 versus 78/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

PlexusDx

Trillium Meds

Semaglutide / month
PlexusDx: $189/moSame price at every dose, month to month, compounded, all-inclusive; $169/mo on a 3-month plan, $149/mo on a 6-month plan
Trillium Meds: $159/moAll doses, compounded
Tirzepatide / month
PlexusDx: $289/moSame price at every dose, month to month, compounded, all-inclusive; $269/mo on a 3-month plan, $249/mo on a 6-month plan
Trillium Meds: $199/moAny dose, compounded; pharmacy-specific plans
Semaglutide / year (modeled)
PlexusDx: $2,268
Trillium Meds: $1,908
Tirzepatide / year (modeled)
PlexusDx: $3,468
Trillium Meds: $2,388
State availability
PlexusDx: All 50 states
Trillium Meds: All 50 states
Oral / sublingual option listed
PlexusDx: Yes
Trillium Meds: Not listed
Brand-name access listed
PlexusDx: Not confirmed
Trillium Meds: Not confirmed
Provider facts checked
PlexusDx: October 2026
Trillium Meds: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

PlexusDx

Shoppers who want one price at every dose, an oral option for either molecule, and all 50 states.

Reasons to consider it

  • LegitScript Certified, with the seal on the homepage
  • Same price at every dose, with no membership: semaglutide $189 and tirzepatide $289 month to month, less on 3- and 6-month plans
  • Both molecules come as weekly injections or daily tablets

What to weigh up

  • The 'starts at' $149 and $249 figures are 6-month-plan prices; month to month, semaglutide is $189 and tirzepatide $289
  • The tablets cost more than the shots: oral semaglutide starts at $249/mo and oral tirzepatide at $279/mo on the 6-month plan
  • No named prescriber, medical director, or specific compounding pharmacy

Compounded drugs are not FDA-approved. Understand the medication options.

Check PlexusDx pricing Read the full PlexusDx review

Trillium Meds

Shoppers who want compounded GLP-1 in all 50 states with a real month-to-month option and a cheaper 3-month prepay.

Reasons to consider it

  • Names pharmacy partners and displays their plan totals, formulations and shipping restrictions
  • One-month and prepaid options are published before intake
  • One-month semaglutide $159 and tirzepatide $199 offers cover any prescribed dose at several pharmacies

What to weigh up

  • Lower prepaid averages require buying multiple months at once; plans and state restrictions differ by pharmacy
  • The pharmacy card and actual fulfillment pharmacy can differ; Hyalo lists NewLife and Nova lists White Label as fulfillment partners
  • Pharmacy choice depends on availability and can be changed by the provider or pharmacy

Compounded drugs are not FDA-approved. Understand the medication options.

Check Trillium Meds pricing Read the full Trillium Meds review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

PlexusDxTrillium Meds
Normalized Cost/Month
PlexusDx:
76/100
Trillium Meds:
80/100
Price Transparency
PlexusDx:
94/100
Trillium Meds:
97/100
Nationwide Access
PlexusDx:
86/100
Trillium Meds:
86/100
Formulation Options
PlexusDx:
77/100
Trillium Meds:
66/100
Clinical Oversight
PlexusDx:
74/100
Trillium Meds:
89/100
Contract Flexibility
PlexusDx:
55/100
Trillium Meds:
25/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.