PlexusDx vs He & She MD

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

PlexusDx

Provider comparison

Shoppers who want one price at every dose, an oral option for either molecule, and all 50 states.

Semaglutide / month: $189/moSame price at every dose, month to month, compounded, all-inclusive; $169/mo on a 3-month plan, $149/mo on a 6-month plan
Tirzepatide / month: $289/moSame price at every dose, month to month, compounded, all-inclusive; $269/mo on a 3-month plan, $249/mo on a 6-month plan

Index 79/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check PlexusDx pricing Read review

He & She MD

Provider comparison

Readers comparing monthly treatment against prepaid terms who will resolve conflicting product-page prices before paying.

Semaglutide / month: $199/moMonth to month, compounded; every lower rate is a prepaid term
Tirzepatide / month: $299/moMonth to month, compounded; every lower rate is a prepaid term

Index 79/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check He & She MD pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Both score 79/100 on the Cost-Efficiency Index. There is no score winner; compare the treatment you need, billing terms and state availability.

Check the difference in state access

PlexusDx: All 50 states
He & She MD: 49 states, excluding Louisiana (GLP-1)

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

PlexusDx

He & She MD

Semaglutide / month: PlexusDx: $189/moSame price at every dose, month to month, compounded, all-inclusive; $169/mo on a 3-month plan, $149/mo on a 6-month plan; He & She MD: $199/moMonth to month, compounded; every lower rate is a prepaid term

Tirzepatide / month: PlexusDx: $289/moSame price at every dose, month to month, compounded, all-inclusive; $269/mo on a 3-month plan, $249/mo on a 6-month plan; He & She MD: $299/moMonth to month, compounded; every lower rate is a prepaid term

Semaglutide / year (modeled): PlexusDx: $2,268; He & She MD: $2,388

Tirzepatide / year (modeled): PlexusDx: $3,468; He & She MD: $3,588

State availability: PlexusDx: All 50 states; He & She MD: 49 states, excluding Louisiana (GLP-1)

Oral / sublingual option listed: PlexusDx: Yes; He & She MD: Yes

Brand-name access listed: PlexusDx: Not confirmed; He & She MD: Yes

Provider facts checked: PlexusDx: October 2026; He & She MD: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

PlexusDx

Shoppers who want one price at every dose, an oral option for either molecule, and all 50 states.

Reasons to consider it

LegitScript Certified, with the seal on the homepage
Same price at every dose, with no membership: semaglutide $189 and tirzepatide $289 month to month, less on 3- and 6-month plans
Both molecules come as weekly injections or daily tablets

What to weigh up

The 'starts at' $149 and $249 figures are 6-month-plan prices; month to month, semaglutide is $189 and tirzepatide $289
The tablets cost more than the shots: oral semaglutide starts at $249/mo and oral tirzepatide at $279/mo on the 6-month plan
No named prescriber, medical director, or specific compounding pharmacy

Compounded drugs are not FDA-approved. Understand the medication options.

Check PlexusDx pricing Read the full PlexusDx review

He & She MD

Readers comparing monthly treatment against prepaid terms who will resolve conflicting product-page prices before paying.

Reasons to consider it

Offers compounded semaglutide and tirzepatide injections and oral options, plus branded GLP-1 prescribing
Names Dr. Ozita Cooper as CMO, Wasef Health as the provider group, and two dispensing partners: Jungle Jim's Pharmacy and GoGoMeds
Publishes monthly, quarterly, six-month and annual plans

What to weigh up

The plans page lists $199 semaglutide and $299 tirzepatide monthly, but the individual injection pages list $249 and $339 for one month; confirm the actual bill
Quarterly, six-month and annual prices require the whole term paid upfront; six-month promotional terms may renew higher
The FAQ says Jungle Jim's cannot dispense sterile compounds and lists state exclusions; ask which partner fills your injectable prescription

Compounded drugs are not FDA-approved. Understand the medication options.

Check He & She MD pricing Read the full He & She MD review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

PlexusDxHe & She MD

Normalized Cost/Month: PlexusDx:
76/100; He & She MD:
78/100

Price Transparency: PlexusDx:
94/100; He & She MD:
97/100

Nationwide Access: PlexusDx:
86/100; He & She MD:
78/100

Formulation Options: PlexusDx:
77/100; He & She MD:
90/100

Clinical Oversight: PlexusDx:
74/100; He & She MD:
85/100

Contract Flexibility: PlexusDx:
55/100; He & She MD:
31/100

Before you sign up

Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.