Head-to-head · Cost-Efficiency Index
Nucore Health vs SkyRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Nucore Health
Shoppers who want a single flat monthly price regardless of dose and don't need tirzepatide.
Visit Nucore HealthSkyRx
Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.
Visit SkyRxThe verdict
Nucore Health and SkyRx tie on the Cost-Efficiency Index at 55/100, so neither wins outright on the numbers. For most shoppers we'd start with Nucore Health (ranked #341, a hair above #346) — Shoppers who want a single flat monthly price regardless of dose and don't need tirzepatide. But SkyRx is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Nucore Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Nucore Health | SkyRx |
|---|---|---|
| Cost-Efficiency Index | 55/100 | 55/100 |
| Semaglutide / mo | $299/mo (all doses, compounded) | $199/mo (compounded) |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | $3,588 | $2,388 |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #341 | #346 |
Nucore Health
55/100Where the value is
- Flat $299/month price for semaglutide regardless of dose tier, easy to budget
- LegitScript certification badge displayed
- Claims nationwide coverage across all 50 states
The tradeoffs
- No tirzepatide pricing found
- Named pharmacy partner (Fullscript) is atypical for compounded injectables, unclear who actually fulfills the semaglutide prescription
SkyRx
55/100Where the value is
- Simple, single headline price displayed on the weight-loss page
- Claims LegitScript certification
- Straightforward telehealth intake flow
The tradeoffs
- The '$199/mo' price is a 12-month prepay rate, not a cancel-anytime monthly price -- a major disclosure trap
- Tirzepatide not yet available ('coming soon'), so half the category is unpriced
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.