Head-to-head · Cost-Efficiency Index
Fifty 410 vs AskRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Fifty 410
Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Visit Fifty 410AskRx
Patients who specifically want FDA-approved branded Wegovy/Zepbound/Foundayo and don't need to see the drug price before starting intake.
Visit AskRxThe verdict
Fifty 410 and AskRx tie on the Cost-Efficiency Index at 59/100, so neither wins outright on the numbers. For most shoppers we'd start with Fifty 410 (ranked #263, a hair above #266) — Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum. But AskRx is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Fifty 410.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Fifty 410 | AskRx |
|---|---|---|
| Cost-Efficiency Index | 59/100 | 59/100 |
| Semaglutide / mo | $199/mo (all doses, compounded) | Not disclosed |
| Tirzepatide / mo | $133/mo (starting dose, 3-month plan, compounded) | Not disclosed |
| Semaglutide / yr (modeled) | $2,388 | — |
| Tirzepatide / yr (modeled) | $1,596 | — |
| Coverage | Coverage not published | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Yes |
| Rank here | #263 | #266 |
Fifty 410
59/100Where the value is
- No recurring subscription — you pay once per order and are not auto-billed
- Transparent per-tier tirzepatide totals ($399/$499/$549) shown alongside the per-month math, so the real charge is visible if you read past the headline
- Free overnight/2-day shipping and refrigerated packaging included in every tier
The tradeoffs
- Tirzepatide's advertised '$133/month' is a 3-month prepay of $399 charged in one transaction, not a monthly recurring price — the cheapest advertised number is not what most shoppers will assume
- Semaglutide has no discounted multi-month tier and, at $199 flat, actually costs more per month than tirzepatide's cheapest bundle
Regulatory note: the FDA issued a warning letter to Aspen Aesthetics dba Fifty 410 in February 2026. We still list and link to Fifty 410; you should know the letter is on the public record before you decide.
AskRx
59/100Where the value is
- Sells only FDA-approved branded medication ('never compounded'), removing compounding-related sourcing questions entirely
- States a clear, itemized flat care fee ($90 visit + $10 fulfillment = $100/mo) rather than folding an undisclosed markup into the drug price
- Explicitly states no markup is added to the medication's pharmacy cost
The tradeoffs
- The actual medication price — the majority of the real monthly cost for a brand-name GLP-1 — is never published; it's shown only at checkout after intake, so the site cannot be used to comparison-shop the true total cost
- Live video visits are limited to 'select states' despite the blanket '50 States' coverage claim, an inconsistency the site doesn't reconcile
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.