Head-to-head · Cost-Efficiency Index
Blis MD vs Cost Plus Drugs
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Blis MD
Shoppers who want the lowest flat, dose-independent price found in this batch and don't need pharmacy/state transparency upfront.
Visit Blis MDCost Plus Drugs
Cost-first shoppers who want the cheapest transparent-pricing brand-name Ozempic channel.
Visit Cost Plus DrugsThe verdict
Blis MD and Cost Plus Drugs tie on the Cost-Efficiency Index at 64/100, so neither wins outright on the numbers. For most shoppers we'd start with Blis MD (ranked #174, a hair above #177) — Shoppers who want the lowest flat, dose-independent price found in this batch and don't need pharmacy/state transparency upfront. But Cost Plus Drugs is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Blis MD.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Blis MD | Cost Plus Drugs |
|---|---|---|
| Cost-Efficiency Index | 64/100 | 64/100 |
| Semaglutide / mo | $109/mo (compounded) | $279/mo (brand Ozempic) |
| Tirzepatide / mo | $159/mo (compounded) | Not disclosed |
| Semaglutide / yr (modeled) | $1,308 | $3,348 |
| Tirzepatide / yr (modeled) | $1,908 | — |
| Coverage | Coverage not published | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #174 | #177 |
Blis MD
64/100Where the value is
- Genuinely low flat pricing — $109/mo semaglutide and $159/mo tirzepatide, both below most peers researched here
- Free initial consultation with a licensed provider
- Flat pricing regardless of dose tier (no escalation disclosed)
The tradeoffs
- No compounding pharmacy named anywhere on the site
- No named medical director or prescriber found
Cost Plus Drugs
64/100Where the value is
- Transparent pricing: wholesale cost + 15% markup + $5 pharmacy fee, the same for everyone
- Around $279/mo for branded Ozempic — well below typical retail list prices
- Mark Cuban's PBM-disrupting pharmacy, praised by Forbes Health, Wired, and KFF Health News
The tradeoffs
- Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
- Ozempic is FDA-indicated for type 2 diabetes, not weight management — weight-loss use is off-label
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.