Head-to-head · Cost-Efficiency Index
Amble vs Science & Co
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Amble
Cost-first shoppers who want a single flat rate across semaglutide and tirzepatide, if a 12-month prepay is acceptable.
Visit AmbleScience & Co
A twelve-month committer, or someone who values a company stating plainly what it is and is not.
Visit Science & CoThe verdict
Amble and Science & Co tie on the Cost-Efficiency Index at 74/100, so neither wins outright on the numbers. For most shoppers we'd start with Amble (ranked #56, a hair above #62) — Cost-first shoppers who want a single flat rate across semaglutide and tirzepatide, if a 12-month prepay is acceptable. But Science & Co is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Amble.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Amble | Science & Co |
|---|---|---|
| Cost-Efficiency Index | 74/100 | 74/100 |
| Semaglutide / mo | $179/mo (all doses, compounded) | $149/mo month-to-month; $79 only on a twelve-month plan |
| Tirzepatide / mo | $179/mo (all doses, compounded) | $199/mo month-to-month; $125 only on a twelve-month plan |
| Semaglutide / yr (modeled) | $2,148 | $1,788 |
| Tirzepatide / yr (modeled) | $2,148 | $2,388 |
| Coverage | All 50 states | Not disclosed |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #56 | #62 |
Amble
74/100Where the value is
- No difference in price between semaglutide and tirzepatide — genuinely one pricing table for both
- True no-commitment option exists ($179/mo, pay as you go) alongside the prepay tiers
- All 50 states, with only 5 requiring a live video visit instead of async intake
The tradeoffs
- The advertised low-end price ($135-$160/mo) is not a monthly bill — it's a one-time lump-sum prepay for the whole 3/6/12-month term, stated explicitly on the page
- No named medical director, prescriber, or compounding pharmacy anywhere on the site
Science & Co
74/100Where the value is
- States twice in its footer that "Science and Co, Inc. is not a 503A or 503B compounding facility"
- Its own FAQ names the commitment behind the headline: "Plans start at $79 a month on the 12 month plan"
- The printed saving corroborates the reference price — 79 divided by 149 is 53%, exactly the "Save 47%" shown
The tradeoffs
- The number it leads with is a twelve-month commitment; the per-month rates are $149 and $199
- Only two figures are published per drug, so a three- or six-month plan cannot be priced without starting an intake
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.