Head-to-head · Cost-Efficiency Index
ZYP Medical vs Premium Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
ZYP Medical
Cost-first shoppers who want men in IA, NE, SD, MN, KS, CO or AZ wanting a low starter rate with an oral needle-free option.
Visit ZYP MedicalPremium Health
Cost-first shoppers who want an all-inclusive compounded GLP-1 membership with three named pharmacy partners, if you won't need the higher dose tiers.
Visit Premium HealthThe verdict
ZYP Medical takes it, leading the Cost-Efficiency Index 56 to 55. ZYP Medical is a men's-health-oriented telehealth practice now covering seven Midwest/Mountain states (recently adding Minnesota) with both injectable and oral (ODT) tirzepatide. Premium Health still earns a C — Cost-first shoppers who want an all-inclusive compounded GLP-1 membership with three named pharmacy partners, if you won't need the higher dose tiers.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs ZYP Medical.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | ZYP Medical | Premium Health |
|---|---|---|
| Cost-Efficiency Index | 56/100 | 55/100 |
| Semaglutide / mo | $150/mo (starting dose, 3 month plan, plus a separate fee, compounded) | $275/mo (compounded) |
| Tirzepatide / mo | $233/mo (starting dose, 3 month plan, plus a separate fee, compounded) | $445/mo (compounded) |
| Semaglutide / yr (modeled) | $1,800 | $3,300 |
| Tirzepatide / yr (modeled) | $2,796 | $5,340 |
| Coverage | 6 states | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #333 | #335 |
ZYP Medical
56/100Where the value is
- Offers a genuine needle-free oral tirzepatide (ODT) option, not just injectable
- Consult fee is disclosed and itemized ($50, or $29.99 for a shorter returning-patient visit)
- Recently expanded to 7 states (added Minnesota)
The tradeoffs
- Advertised $150/$233 prices are explicitly labeled 'starter plans (initial 3 months)' — what they become after 3 months is not published anywhere on the site
- One-time consult fee ($29.99-$50) is charged on top of the medication price and is non-refundable once the visit occurs
Premium Health
55/100Where the value is
- All-inclusive flat pricing stated to cover medical consultation, provider visits, medication, supplies, and shipment in one number
- Month-to-month with 'the option to cancel anytime if unsatisfied' — no long-term contract
- Names three real, licensed pharmacy partners (Hallandale Pharmacy, Red Rock Pharmacy, Strive Pharmacy)
The tradeoffs
- The $275/$445 base price is NOT the ceiling: reaching the higher labeled doses costs an additional $100/mo or $150/mo, pushing the real cost to $375-$595/mo
- Compounded medications are not FDA-approved
Regulatory note: the FDA issued a warning letter to Premium Health Management Inc. dba Premium Health in February 2026. We still list and link to Premium Health; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.