Head-to-head · Cost-Efficiency Index
YourHealthRx vs Fifty 410
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
YourHealthRx
Cost-first shoppers who want science-forward GLP-1 and peptide care, flat-rate dosing, built-in follow-up.
Visit YourHealthRxFifty 410
Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Visit Fifty 410The verdict
YourHealthRx takes it, leading the Cost-Efficiency Index 60 to 59. YourHealthRx is a scientist-founded peptide and GLP-1 telehealth platform available in all 50 states and DC via a multi-state (IMLC) clinician network. Fifty 410 still earns a C — Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs YourHealthRx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | YourHealthRx | Fifty 410 |
|---|---|---|
| Cost-Efficiency Index | 60/100 | 59/100 |
| Semaglutide / mo | $170/mo (compounded) | $199/mo (all doses, compounded) |
| Tirzepatide / mo | $210/mo (compounded) | $133/mo (starting dose, 3-month plan, compounded) |
| Semaglutide / yr (modeled) | $2,040 | $2,388 |
| Tirzepatide / yr (modeled) | $2,520 | $1,596 |
| Coverage | All 50 states | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #260 | #263 |
YourHealthRx
60/100Where the value is
- Available in all 50 states and DC through a multi-state (IMLC) licensed clinician network
- Compounded semaglutide and tirzepatide in two formats - weekly injectable (with B12) or daily oral dissolving tablet
- Flat subscription price that doesn't change as your dose increases (no titration penalty)
The tradeoffs
- Eligibility and prescribing run through partner clinical workflows - YourHealthRx is the platform, not the prescriber or pharmacy
- Compounded medications are not FDA-approved - not brand Wegovy, Ozempic, Zepbound, or Mounjaro
Fifty 410
59/100Where the value is
- No recurring subscription — you pay once per order and are not auto-billed
- Transparent per-tier tirzepatide totals ($399/$499/$549) shown alongside the per-month math, so the real charge is visible if you read past the headline
- Free overnight/2-day shipping and refrigerated packaging included in every tier
The tradeoffs
- Tirzepatide's advertised '$133/month' is a 3-month prepay of $399 charged in one transaction, not a monthly recurring price — the cheapest advertised number is not what most shoppers will assume
- Semaglutide has no discounted multi-month tier and, at $199 flat, actually costs more per month than tirzepatide's cheapest bundle
Regulatory note: the FDA issued a warning letter to Aspen Aesthetics dba Fifty 410 in February 2026. We still list and link to Fifty 410; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.