Head-to-head · Cost-Efficiency Index
Vyora Wellness vs JRNYS
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Vyora Wellness
Shoppers who want one flat price that never changes as their GLP-1 dose is titrated up.
Visit Vyora WellnessJRNYS
Cost-first shoppers who want branded GLP-1s with coaching through insurance, and can accept learning the medication price only after a consultation.
Visit JRNYSThe verdict
Vyora Wellness takes it, leading the Cost-Efficiency Index 52 to 51. Vyora Wellness is a compounded GLP-1 telehealth subscription priced as a genuinely flat rate $299/mo for semaglutide, $399/mo for tirzepatide that does not change as the prescribed dose is titrated up. JRNYS still earns a C — Cost-first shoppers who want branded GLP-1s with coaching through insurance, and can accept learning the medication price only after a consultation.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Vyora Wellness.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Vyora Wellness | JRNYS |
|---|---|---|
| Cost-Efficiency Index | 52/100 | 51/100 |
| Semaglutide / mo | $299/mo (all doses, compounded) | Not disclosed |
| Tirzepatide / mo | $399/mo | Not disclosed |
| Semaglutide / yr (modeled) | $3,588 | — |
| Tirzepatide / yr (modeled) | $4,788 | — |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #393 | #398 |
Vyora Wellness
52/100Where the value is
- Genuinely flat-rate pricing confirmed by its own FAQ — the monthly cost does not rise as the dose increases, unlike per-dose-tier competitors
- LegitScript certification verified to actually render on the live homepage (real badge and outbound verification link, not commented-out code)
- Coaching, nutritional guidance, and community access are bundled into the price at no extra charge
The tradeoffs
- Above-average flat pricing ($299-$399/mo) compared to per-dose-tier or 12-month-prepay competitors that can undercut it at low starting doses
- No specific compounding pharmacy is named — only a generic '503A certified pharmacies' claim
JRNYS
51/100Where the value is
- Branded, FDA-approved GLP-1s — Wegovy, Ozempic, Zepbound, Mounjaro and Saxenda — rather than compounded copies
- The membership band is published before intake and is banded openly by level of coach support
- Medical visits, daily monitoring and 1-on-1 coaching are included in the membership at every tier
The tradeoffs
- The membership is overhead, not a medication price: it covers visits, monitoring and coaching, and the FAQ says medication pricing is confirmed only after a provider consultation
- No self-pay drug price is published anywhere, so the cost of a month cannot be worked out before signing up
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.