Head-to-head · Cost-Efficiency Index
Trinity Meds vs Tuyo Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Trinity Meds
Cost-first shoppers who want price-sensitive shoppers comfortable prepaying 6-12 months to lock in the lowest per-month rate.
Visit Trinity MedsTuyo Health
Shoppers who want a low advertised floor price and are willing to confirm the actual dose-tier cost before committing.
Visit Tuyo HealthThe verdict
Trinity Meds takes it, leading the Cost-Efficiency Index 58 to 57. Trinity Meds (trinitymeds.com) is a LegitScript-certified, 50-state telehealth platform prescribing compounded semaglutide ($99/mo) and tirzepatide ($149/mo) through the OpenLoop Health provider network. Tuyo Health still earns a C — Shoppers who want a low advertised floor price and are willing to confirm the actual dose-tier cost before committing.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Trinity Meds.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Trinity Meds | Tuyo Health |
|---|---|---|
| Cost-Efficiency Index | 58/100 | 57/100 |
| Semaglutide / mo | $99/mo (starting dose, compounded) | $155/mo (starting dose, compounded) |
| Tirzepatide / mo | $149/mo (starting dose, compounded) | $279/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $1,188 | $1,860 |
| Tirzepatide / yr (modeled) | $1,788 | $3,348 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #294 | #298 |
Trinity Meds
58/100Where the value is
- LegitScript Certified with a displayed seal
- Transparent tiered pricing table (month-to-month through 12-month prepay) all shown up front
- Four named, identifiable compounding pharmacy partners
The tradeoffs
- Headline $99/$149 pricing sits under a manufactured-urgency 'Was $299' countdown-timer promo with an unverifiable anchor price
- Cheapest per-month rates require 12-month prepayment, not simple monthly billing
Tuyo Health
57/100Where the value is
- Quarterly lab work is explicitly bundled into the compounded-track price, unlike sites that omit lab monitoring entirely
- Offers both compounded and branded (insurance-eligible) tracks on the same platform
- LegitScript certified
The tradeoffs
- Both headline prices are explicit 'as low as' floors with no dose-tier table published — the real cost for a titrated-up dose is unknown from the site
- No compounding pharmacy or individual prescriber/medical director named anywhere on the page
Regulatory note: the FDA issued a warning letter to Tuyo Health, Inc. dba Tuyo Health in September 2025. We still list and link to Tuyo Health; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.