Head-to-head · Cost-Efficiency Index
Trillium Meds vs Nova
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Trillium Meds
Cost-first shoppers who want all-50-state compounded GLP-1 with a real month-to-month option and a cheaper 3-month prepay path.
Visit Trillium MedsNova
Readers who want the membership inside the quoted price rather than added to it, and who want a daily sublingual option beside the injection.
Visit NovaThe verdict
Trillium Meds takes it, leading the Cost-Efficiency Index 73 to 72. Trillium Meds is a small, Portland-OR-based telehealth platform connecting patients to independent licensed providers and compounding pharmacies for GLP-1 therapy, serving all 50 states plus Puerto Rico. Nova still earns a C — Readers who want the membership inside the quoted price rather than added to it, and who want a daily sublingual option beside the injection.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Trillium Meds.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Trillium Meds | Nova |
|---|---|---|
| Cost-Efficiency Index | 73/100 | 72/100 |
| Semaglutide / mo | $159/mo (all doses, compounded) | $198/mo month-to-month all-in (medication plus the $99/mo membership; a "Starting at" floor that rises with dose) |
| Tirzepatide / mo | $249/mo (all doses, compounded) | $210/mo month-to-month all-in (same bundle; also a "Starting at" floor) |
| Semaglutide / yr (modeled) | $1,908 | $2,376 |
| Tirzepatide / yr (modeled) | $2,988 | $2,520 |
| Coverage | All 50 states | 49 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #65 | #72 |
Trillium Meds
73/100Where the value is
- Discloses both a real month-to-month rate ($159/$249) and the 3-month prepay rate, rather than only advertising the lower prepay number
- LegitScript certified, all 50 states plus Puerto Rico, with a real street address published
- Syringes and alcohol wipes included; Klarna and Affirm financing available
The tradeoffs
- The lowest advertised rate ($119/mo semaglutide, ~$200/mo tirzepatide) requires a $357 or $599 upfront 3-month payment, not a standing monthly charge
- Partner pharmacy names are referenced in the FAQ structure but were not visible in the page text pulled this session — re-verify before citing a specific pharmacy
Nova
72/100Where the value is
- Quotes one all-in figure that already contains the $99 monthly membership, the medication and refrigerated shipping, so the membership is not a surprise at checkout
- Names a medical director and a nurse practitioner with credentials, training and residency detail
- Prices a daily oral route for both molecules alongside the weekly injections
The tradeoffs
- Three sets of prices are live at once: $198 and $210 in the hero, $229 and $279 in the same pages' own FAQ headings, and a third set in the site's JavaScript
- The FAQ's own arithmetic does not reach the headline — $99 membership plus $130 medication is $229, not the $198 quoted above it
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.