Head-to-head · Cost-Efficiency Index
TMates vs Vyvron
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
TMates
Shoppers who want a flat price at every dose, with an oral semaglutide option and a provider who can also prescribe brand Wegovy or Zepbound.
Visit TMatesVyvron
Shoppers who want one all-in price with no membership fee and are comfortable budgeting for a four-week billing cycle.
Visit VyvronThe verdict
TMates and Vyvron tie on the Cost-Efficiency Index at 68/100, so neither wins outright on the numbers, so choose on fit. TMates: Shoppers who want a flat price at every dose, with an oral semaglutide option and a provider who can also prescribe brand Wegovy or Zepbound. Vyvron: Shoppers who want one all-in price with no membership fee and are comfortable budgeting for a four-week billing cycle.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs TMates.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | TMates | Vyvron |
|---|---|---|
| Cost-Efficiency Index | 68/100 | 68/100 |
| Semaglutide / mo | $249/moMonth to month, same price at every dose, compounded | $199Every 4 weeks (founding-member price; $249 after the founding spots fill, compounded) |
| Tirzepatide / mo | $297/moMonth to month, same price at every dose, compounded | Not disclosed |
| Semaglutide / yr (modeled) | $2,988 | $2,58713 charges |
| Tirzepatide / yr (modeled) | $3,564 | — |
| Coverage | Not published ("most states") | 49 states (not Mississippi) |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #160 | #162 |
TMates
68/100Where the value is
- Each product page lists every plan: semaglutide is $249 for one month, $650 for three, $1,050 for six and $1,900 for twelve; tirzepatide is $297, $800, $1,299 and $1,999
- The price covers the medication, telemedicine visits and coaching, and stays the same at every dose
- Semaglutide comes as a weekly injection or an oral option, and brand Wegovy or Zepbound can be prescribed for $99 a month to fill at your own pharmacy
The tradeoffs
- The "from $158" and "from $167" category prices are 12-month prepaid rates; month to month is $249 and $297
- No refund once your prescription is sent to the pharmacy
Vyvron
68/100Where the value is
- One price covers the provider evaluation, the medication if prescribed, ongoing check-ins and shipping, with no membership fee
- No long-term contract and no cancellation fee; you cancel by email or in the patient portal
- Full refund if a provider doesn't approve you
The tradeoffs
- Billing is every four weeks, not monthly, so a year at $199 is 13 charges and $2,587
- The pages don't say whether tirzepatide costs the same as semaglutide; the provider chooses which one you get
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.