Head-to-head · Cost-Efficiency Index
Sprout Health vs RxSpan MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Sprout Health
Price-first shoppers who want a fast, low-friction signup (often no labs or visit) at a verified pharmacy and don't need a named medical director.
Visit Sprout HealthRxSpan MD
Someone who wants to compare a compounded route against brand-name Zepbound or Wegovy without leaving one provider, and who will read past the twelve-month figure.
Visit RxSpan MDThe verdict
Sprout Health takes it, leading the Cost-Efficiency Index 85 to 83. Low-friction and well-priced — $149 compounded semaglutide and $199 tirzepatide from a LegitScript-certified operator, with a brand Wegovy/Zepbound path if you want to step up. RxSpan MD still earns a B — Someone who wants to compare a compounded route against brand-name Zepbound or Wegovy without leaving one provider, and who will read past the twelve-month figure.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Sprout Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Sprout Health | RxSpan MD |
|---|---|---|
| Cost-Efficiency Index | 85/100 | 83/100 |
| Semaglutide / mo | $149/mo | $249/mo month-to-month for the injection; $219 on three months, $199 on six and $194 on twelve |
| Tirzepatide / mo | $199/mo | $329/mo month-to-month for the injection; $309 on three months, $289 on six and $269 on twelve |
| Semaglutide / yr (modeled) | $1,788 | $2,988 |
| Tirzepatide / yr (modeled) | $2,388 | $3,948 |
| Coverage | Most states | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Yes | Yes |
| Rank here | #10 | #17 |
Sprout Health
85/100Where the value is
- Well-priced compounded — $149 semaglutide / $199 tirzepatide — with LegitScript certification behind it
- Low-friction intake: no labs and often no synchronous visit required
- Offers a brand-name Wegovy/Zepbound path alongside the compounded route
The tradeoffs
- No named medical director published, so clinical oversight is harder to attribute
- Availability is quiz-gated by state, so nationwide access isn't guaranteed until you qualify
Regulatory note: the FDA issued a warning letter to Sprout Health Partners LLC dba Sprout Health in September 2025. We still list and link to Sprout Health; you should know the letter is on the public record before you decide.
RxSpan MD
83/100Where the value is
- Every product and every term carries a published price, including the brand-name lane: Zepbound and Mounjaro at $1,069, Ozempic at $1,299 and Wegovy at $1,349
- Five routes on one account — injection, oral capsule, orally dissolving tablet, microdose injection and brand — which is the broadest formulary of anything ranked here
- A physician-founded program serving all 50 states
The tradeoffs
- The storefront renders no price at all without JavaScript: the catalog is reachable, but a reader with a blocked script sees nothing
- The figure a reader is most likely to meet elsewhere, around $194, is the twelve-month per-month rate; one month of the semaglutide injection is $249
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.