Head-to-head · Cost-Efficiency Index
SkyRx vs TelePeptide
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
SkyRx
Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.
Visit SkyRxTelePeptide
Cost-first shoppers who want all-in compounded GLP-1 from $169/mo; LegitScript-certified, 48 states.
Visit TelePeptideThe verdict
SkyRx and TelePeptide tie on the Cost-Efficiency Index at 55/100, so neither wins outright on the numbers. For most shoppers we'd start with SkyRx (ranked #346, a hair above #348) — Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate. But TelePeptide is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs SkyRx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | SkyRx | TelePeptide |
|---|---|---|
| Cost-Efficiency Index | 55/100 | 55/100 |
| Semaglutide / mo | $199/mo (compounded) | $199/mo (starting dose, annual plan, compounded oral) |
| Tirzepatide / mo | Not disclosed | $219/mo (starting dose, annual plan, compounded oral) |
| Semaglutide / yr (modeled) | $2,388 | $2,388 |
| Tirzepatide / yr (modeled) | — | $2,628 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #346 | #348 |
SkyRx
55/100Where the value is
- Simple, single headline price displayed on the weight-loss page
- Claims LegitScript certification
- Straightforward telehealth intake flow
The tradeoffs
- The '$199/mo' price is a 12-month prepay rate, not a cancel-anytime monthly price -- a major disclosure trap
- Tirzepatide not yet available ('coming soon'), so half the category is unpriced
TelePeptide
55/100Where the value is
- LegitScript-certified (seal ID 49966407); 503A-licensed compounding pharmacies
- All-inclusive from $169/mo annual — physician eval + Rx + medication + shipping, no hidden fees
- Broadest formulation menu: injectable sema/tirz, oral dissolvable tablets, sema+naltrexone, microdose combos
The tradeoffs
- Compounded medications are not FDA-approved; no pharmacy partner named publicly
- Monthly billing costs more — $199/mo (monthly) vs $169/mo (annual) for semaglutide injectable; best rate requires annual prepay
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.