Head-to-head · Cost-Efficiency Index
Silhouette MD vs Ascend Vitality
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Silhouette MD
Cost-first shoppers who want unclear -- insufficient public pricing to recommend a specific buyer profile.
Visit Silhouette MDAscend Vitality
Cost-first shoppers who want cash-pay compounded GLP-1 in both injectable and oral-tablet form, outside LA/MS/KS/NM/WV.
Visit Ascend VitalityThe verdict
Silhouette MD takes it, leading the Cost-Efficiency Index 43 to 42. Silhouette MD advertises a 'concierge-style' GLP-1 telehealth offering but discloses no base pricing anywhere on its site -- only a '$75 off your first month' promo with no visible starting price to discount from. Ascend Vitality still earns a C — Cost-first shoppers who want cash-pay compounded GLP-1 in both injectable and oral-tablet form, outside LA/MS/KS/NM/WV.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Silhouette MD.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Silhouette MD | Ascend Vitality |
|---|---|---|
| Cost-Efficiency Index | 43/100 | 42/100 |
| Semaglutide / mo | Not disclosed | $199/mo (plus a separate fee, compounded) |
| Tirzepatide / mo | Not disclosed | $299/mo (compounded) |
| Semaglutide / yr (modeled) | — | $2,388 |
| Tirzepatide / yr (modeled) | — | $3,588 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #503 | #510 |
Silhouette MD
43/100Where the value is
- LegitScript badge verified specifically for the silhouette-md.com domain
- Markets itself around GLP-1 injectables specifically, not a broad general-health platform
The tradeoffs
- No base price published anywhere -- the '$75 off first month' promo has no visible starting price
- No named medical director
Ascend Vitality
42/100Where the value is
- Both injectable and oral-tablet forms of semaglutide and tirzepatide are offered — a rare combination
- LegitScript certified, with '503A Pharmacy Approved' and FDA-approved-facility manufacturing claims displayed
- Real 6-month prepay discount on semaglutide ($199/mo down to $176/mo), not just a first-month teaser
The tradeoffs
- The homepage's 'Fall Promo Applied! $120 Off' banner is layered on top of the $199/$299 base price, so the number a shopper sees first is a temporary promotional rate
- All medications are compounded — not FDA-reviewed for safety or effectiveness
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.