Head-to-head · Cost-Efficiency Index
Rylo Health vs EdgeRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Rylo Health
Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.
Visit Rylo HealthEdgeRx
Men who also want adjacent peptide, longevity, and hormone protocols (MICC, sermorelin, NAD+, PT-141) bundled with GLP-1 on one account.
Visit EdgeRxThe verdict
Rylo Health takes it, leading the Cost-Efficiency Index 75 to 74. Rylo Health is a compounded GLP-1/NAD+/peptide telehealth platform operating in all 50 states through Lone Star Virtual Health PLLC and dispensing via VialsRX in Houston, TX. EdgeRx still earns a C — Men who also want adjacent peptide, longevity, and hormone protocols (MICC, sermorelin, NAD+, PT-141) bundled with GLP-1 on one account.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Rylo Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Rylo Health | EdgeRx |
|---|---|---|
| Cost-Efficiency Index | 75/100 | 74/100 |
| Semaglutide / mo | $149/mo (all doses, promotional rate, compounded) | $229/mo (once-weekly injectable) |
| Tirzepatide / mo | $249/mo (all doses, compounded) | $299/mo (once-weekly injectable) |
| Semaglutide / yr (modeled) | $1,788 | $2,748 |
| Tirzepatide / yr (modeled) | $2,988 | $3,588 |
| Coverage | All 50 states | 46 states — excludes Arkansas, Indiana, Minnesota, South Carolina |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #52 | #55 |
Rylo Health
75/100Where the value is
- Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
- Medication, provider review, and shipping all stated as included in the quoted price with no add-ons found
- Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous
The tradeoffs
- The '$100/$160 First 20 rate' shown prominently on the homepage is limited to the first 20 signups only — most shoppers will pay the higher $149/$249 standard rate, and the promo framing can make the real price look lower than it is
- The advertised 'quarterly $349/$499' option's actual billing mechanics (one-time total vs. recurring monthly-under-commitment) could not be verified — the product pages that would clarify this render via JavaScript and returned no readable pricing text
EdgeRx
74/100Where the value is
- Named Chief Medical Advisor (Dr. John Starke, MD, ABEM board-certified) sets clinical/dosing standards
- Named compounding pharmacy — Strive Pharmacy, a 503A facility operating since 2018
- LegitScript certified, with a specific, named state-exclusion list rather than a vague coverage claim
The tradeoffs
- Men's-only positioning — explicitly not a fit for women readers
- Dr. Starke sets standards but does not personally prescribe; the actual prescribing pool is an unnamed pool of licensed physicians
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.