Head-to-head · Cost-Efficiency Index
RxPros vs Mixx Health & Wellness
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
RxPros
Shoppers who want the lowest ongoing per-month compounded rate and don't mind a higher-priced first order.
Visit RxProsMixx Health & Wellness
Cost-first shoppers who want wanting a named medical director and named compounding pharmacy, and requesting a tirzepatide quote directly since it isn't published.
Visit Mixx Health & WellnessThe verdict
RxPros and Mixx Health & Wellness tie on the Cost-Efficiency Index at 68/100, so neither wins outright on the numbers. For most shoppers we'd start with RxPros (ranked #120, a hair above #126) — Shoppers who want the lowest ongoing per-month compounded rate and don't mind a higher-priced first order. But Mixx Health & Wellness is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs RxPros.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | RxPros | Mixx Health & Wellness |
|---|---|---|
| Cost-Efficiency Index | 68/100 | 68/100 |
| Semaglutide / mo | $100/mo (all doses, compounded) | $120/mo (starting dose, compounded) |
| Tirzepatide / mo | $145/mo (all doses, compounded) | Not disclosed |
| Semaglutide / yr (modeled) | $1,200 | $1,440 |
| Tirzepatide / yr (modeled) | $1,740 | — |
| Coverage | Coverage not published | 44 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #120 | #126 |
RxPros
68/100Where the value is
- Flat recurring price of $99.97/mo (sema) and $144.97/mo (tirz) — no per-mg price increase as you titrate up doses
- No membership fee and no mandatory commitment despite an annual-prepay discount option — 'Cancel Subscription Anytime' stated directly
- Ships a 3-month supply per order rather than monthly reshipments
The tradeoffs
- The advertised $99.97/mo (sema) and $144.97/mo (tirz) rates are NOT what a first-time buyer pays — the actual first order is $149 and $249 respectively, 49-72% higher than the headline
- Specific pharmacy partner is not named — a proprietary system routes among unnamed 503A pharmacies and 'cannot guarantee' which one fills any given order
Mixx Health & Wellness
68/100Where the value is
- Named medical director (Dr. James David Lawrence III, MD) and a named, address-and-phone-verified compounding pharmacy (Promise Pharmacy, Palm Harbor, FL) — most peer sites in this batch disclose neither
- Free ($0) consultation and 'Unlimited Check-ins' with no extra charge stated
- Licensed in a genuinely large footprint — 44 states per the site's own count
The tradeoffs
- The only published price, 'Plans starting at $120/mo,' is not broken out by drug — there is no separate tirzepatide/GIP price anywhere on the site even though tirzepatide is clearly offered through the same pharmacy
- A $125 cancellation/prescription-change fee applies if requested within 24 hours of payment, and all payments are stated to be final with non-refundable prescriptions
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.