Head-to-head · Cost-Efficiency Index
Rx.com vs Vytora Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Rx.com
Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.
Visit Rx.comVytora Health
Shoppers who want flat per-dose pricing with a named pharmacy and an optional brand-name fallback, 50 states.
Visit Vytora HealthThe verdict
Rx.com takes it, leading the Cost-Efficiency Index 77 to 76. Prints "No automatic renewals" on the plan card and names the pharmacy that dispenses, with a street address — then advertises another drug's prepay rate. Vytora Health still earns a C — Shoppers who want flat per-dose pricing with a named pharmacy and an optional brand-name fallback, 50 states.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Rx.com.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Rx.com | Vytora Health |
|---|---|---|
| Cost-Efficiency Index | 77/100 | 76/100 |
| Semaglutide / mo | $175/mo month-to-month; $165 on three months and $146 on six | $179/mo (all doses, compounded) |
| Tirzepatide / mo | $285/mo month-to-month; $265 on three months and $259 on six | $199/mo (all doses, 3-month plan, compounded) |
| Semaglutide / yr (modeled) | $2,100 | $2,148 |
| Tirzepatide / yr (modeled) | $3,420 | $2,388 |
| Coverage | 49 states on its plan page; its own banner says all 50 | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #45 | #51 |
Rx.com
77/100Where the value is
- "No automatic renewals" is printed under the plan card itself rather than buried in the terms
- Names Manifest Pharmacy in Greer, South Carolina with a full street address, and MD Integrations as the provider network, on the same page as the price
- One flat price at every dose from 2.5 mg to 15 mg, with the provider visit, injection supplies and cold shipping stated as included
The tradeoffs
- The advertised "$146/mo FOR LIFE" is a six-month prepay on semaglutide; month-to-month tirzepatide is $285
- The plan page says 49 states served while the banner on the same site says all 50
Vytora Health
76/100Where the value is
- Semaglutide pricing is genuinely flat across all doses, not a 'starting at' floor
- 50 states plus DC covered, with per-state video-vs-audio requirements disclosed rather than hidden
- Both compounded and retail brand-name (Mounjaro, Zepbound) options on one platform
The tradeoffs
- The site's own FAQ and pricing page disagree on the 1-month tirzepatide price ($199 vs $249) — get the number confirmed at checkout before assuming either figure
- Brand-name Mounjaro/Zepbound at $1,399/mo is essentially full retail
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.