Head-to-head · Cost-Efficiency Index
Prime Doctor RX vs OrderlyMeds
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Prime Doctor RX
Someone who will convert every figure into four-week cycles before comparing it with anything else here.
Visit Prime Doctor RXOrderlyMeds
Cost-first shoppers who want a first GLP-1 course at a published starter rate, with the standing rate published beside it.
Visit OrderlyMedsThe verdict
Prime Doctor RX takes it, leading the Cost-Efficiency Index 69 to 68. Publishes its whole ladder and honors its own asterisk — then bills every 28 days and labels every price per month. OrderlyMeds still earns a C — Cost-first shoppers who want a first GLP-1 course at a published starter rate, with the standing rate published beside it.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Prime Doctor RX.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Prime Doctor RX | OrderlyMeds |
|---|---|---|
| Cost-Efficiency Index | 69/100 | 68/100 |
| Semaglutide / mo | $249 every four weeks — thirteen charges a year, not twelve | $74/mo (starting dose, 2-mo starter plan, new patients only, compounded) |
| Tirzepatide / mo | $339 every four weeks — thirteen charges a year, not twelve | $299/mo (compounded) |
| Semaglutide / yr (modeled) | $2,988 | $888 |
| Tirzepatide / yr (modeled) | $4,068 | $3,588 |
| Coverage | Confirmed at intake, not published | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #110 | #112 |
Prime Doctor RX
69/100Where the value is
- The full ladder for all three weight-loss products and for TRT sits on the homepage before any intake
- Every card's footnote says the starting price is the 52-week prepay, in full
- The four-week shipping cycle is disclosed in that same footnote rather than left to a bank statement
The tradeoffs
- Its own arithmetic proves the 28-day cycle — $3,497 divided by thirteen is exactly $269, and nothing on the page divides cleanly by calendar months
- A year of month-to-month tirzepatide therefore costs $4,407 rather than the $4,068 per-month pricing implies
OrderlyMeds
68/100Where the value is
- The starter rate and the standing rate are both published, so the step-up is visible before signing up
- No membership fees and no hidden costs, stated as such
- The dose ladder is published: four weeks at 0.25 mg then four weeks at 0.5 mg
The tradeoffs
- The $74 rate is a two-month starter plan billed as $149 up front, and it is open only to patients new to GLP-1 medication; the standing monthly rate is $149
- Tirzepatide has no equivalent standing discount — $299/mo is the ongoing rate
Regulatory note: the FDA issued a warning letter to OrderlyMeds LLC dba OrderlyMeds in June 2026. We still list and link to OrderlyMeds; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.