Head-to-head · Cost-Efficiency Index
Prime Doctor RX vs Cielo
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Prime Doctor RX
Someone who will convert every figure into four-week cycles before comparing it with anything else here.
Visit Prime Doctor RXCielo
Shoppers comfortable committing to an undisclosed-structure 6-month plan for a flat, dose-independent price.
Visit CieloThe verdict
Prime Doctor RX takes it, leading the Cost-Efficiency Index 69 to 68. Publishes its whole ladder and honors its own asterisk — then bills every 28 days and labels every price per month. Cielo still earns a C — Shoppers comfortable committing to an undisclosed-structure 6-month plan for a flat, dose-independent price.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Prime Doctor RX.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Prime Doctor RX | Cielo |
|---|---|---|
| Cost-Efficiency Index | 69/100 | 68/100 |
| Semaglutide / mo | $249 every four weeks — thirteen charges a year, not twelve | $89/mo (all doses, 6-month plan, compounded) |
| Tirzepatide / mo | $339 every four weeks — thirteen charges a year, not twelve | $129/mo (all doses, 6-month plan, compounded) |
| Semaglutide / yr (modeled) | $2,988 | $1,068 |
| Tirzepatide / yr (modeled) | $4,068 | $1,548 |
| Coverage | Confirmed at intake, not published | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #110 | #115 |
Prime Doctor RX
69/100Where the value is
- The full ladder for all three weight-loss products and for TRT sits on the homepage before any intake
- Every card's footnote says the starting price is the 52-week prepay, in full
- The four-week shipping cycle is disclosed in that same footnote rather than left to a bank statement
The tradeoffs
- Its own arithmetic proves the 28-day cycle — $3,497 divided by thirteen is exactly $269, and nothing on the page divides cleanly by calendar months
- A year of month-to-month tirzepatide therefore costs $4,407 rather than the $4,068 per-month pricing implies
Cielo
68/100Where the value is
- Flat pricing regardless of dose for both semaglutide and tirzepatide, avoiding per-mg price escalation during titration
- Free physician consult and free shipping stated as included
- Claims 'Every batch tested', at least asserting quality-control testing exists
The tradeoffs
- The '6-month plan' mechanics are never explained — whether it's a one-time prepayment or a 6-month billing lock is unknown, which is exactly the kind of commitment term that should be disclosed before signup
- No pharmacy, medical director, or prescriber is named anywhere on the accessible site
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.