Head-to-head · Cost-Efficiency Index
Premium Health vs MediRX
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Premium Health
Cost-first shoppers who want an all-inclusive compounded GLP-1 membership with three named pharmacy partners, if you won't need the higher dose tiers.
Visit Premium HealthMediRX
Shoppers who want transparent published pricing and don't mind that prescribing is handled by a third-party clinician network (OpenLoop) rather than an in-house medical team.
Visit MediRXThe verdict
Premium Health and MediRX tie on the Cost-Efficiency Index at 55/100, so neither wins outright on the numbers. For most shoppers we'd start with Premium Health (ranked #335, a hair above #339) — Cost-first shoppers who want an all-inclusive compounded GLP-1 membership with three named pharmacy partners, if you won't need the higher dose tiers. But MediRX is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Premium Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Premium Health | MediRX |
|---|---|---|
| Cost-Efficiency Index | 55/100 | 55/100 |
| Semaglutide / mo | $275/mo (compounded) | $149/mo (starting dose, compounded) |
| Tirzepatide / mo | $445/mo (compounded) | $199/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $3,300 | $1,788 |
| Tirzepatide / yr (modeled) | $5,340 | $2,388 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #335 | #339 |
Premium Health
55/100Where the value is
- All-inclusive flat pricing stated to cover medical consultation, provider visits, medication, supplies, and shipment in one number
- Month-to-month with 'the option to cancel anytime if unsatisfied' — no long-term contract
- Names three real, licensed pharmacy partners (Hallandale Pharmacy, Red Rock Pharmacy, Strive Pharmacy)
The tradeoffs
- The $275/$445 base price is NOT the ceiling: reaching the higher labeled doses costs an additional $100/mo or $150/mo, pushing the real cost to $375-$595/mo
- Compounded medications are not FDA-approved
Regulatory note: the FDA issued a warning letter to Premium Health Management Inc. dba Premium Health in February 2026. We still list and link to Premium Health; you should know the letter is on the public record before you decide.
MediRX
55/100Where the value is
- Publishes specific dollar pricing for both injection and oral-tablet forms of both drugs
- Rare self-disclosed distinction between promotional ($149) and standard ($179) semaglutide pricing
- LegitScript badge displayed on the page
The tradeoffs
- MediRx itself has no named medical director -- all clinical care is outsourced to OpenLoop Health's network
- Tirzepatide's wide $199-$399 range makes the true likely monthly cost at a therapeutic dose unclear
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.