Head-to-head · Cost-Efficiency Index
PlexusDx vs Trellis Vitality
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
PlexusDx
Shoppers who want a published starting price with an oral semaglutide option, all 50 states.
Visit PlexusDxTrellis Vitality
Shoppers who want a low month-to-month GLP-1 price that holds at every dose, with no membership or consultation fee.
Visit Trellis VitalityThe verdict
PlexusDx and Trellis Vitality tie on the Cost-Efficiency Index at 82/100, so neither wins outright on the numbers, so choose on fit. PlexusDx: Shoppers who want a published starting price with an oral semaglutide option, all 50 states. Trellis Vitality: Shoppers who want a low month-to-month GLP-1 price that holds at every dose, with no membership or consultation fee.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs PlexusDx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | PlexusDx | Trellis Vitality |
|---|---|---|
| Cost-Efficiency Index | 82/100 | 82/100 |
| Semaglutide / mo | $149/moAll doses, compounded | $150/moCompounded, month to month; same price at every dose |
| Tirzepatide / mo | $249/moAll doses, compounded | $199/moCompounded, month to month; same price at every dose |
| Semaglutide / yr (modeled) | $1,788 | $1,800 |
| Tirzepatide / yr (modeled) | $2,988 | $2,388 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #26 | #29 |
PlexusDx
82/100Where the value is
- LegitScript Certified, stated directly on the homepage
- Both injection and oral tablet formats for semaglutide from the same starting price
- All 50 states served
The tradeoffs
- 'Starts at' pricing — the page does not disclose what higher doses cost, so $149/$249 is a floor, not what most patients settling into a maintenance dose will pay
- No named prescriber, medical director, or specific compounding pharmacy
Trellis Vitality
82/100Where the value is
- A single table shows one-, three- and six-month prices for both drugs, labeled as per-month prices: semaglutide $150, $140 and $133; tirzepatide $199, $189 and $179
- Same price at every dose, so your cost doesn't rise as you titrate up
- No membership fee, no consultation fee, and you can pause or cancel any time
The tradeoffs
- Its NAD+, glutathione, lipo-MIC and tesamorelin programs show only "starting at" prices with no plan table
- The refund policy says only that refunds are decided order by order
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.