Head-to-head · Cost-Efficiency Index
PepHaūs vs Yucca Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
PepHaūs
People who want a verified all-50 program with both molecules disclosed and will pay mid-market for the peace of mind.
Visit PepHaūsYucca Health
Shoppers who want a flat monthly price that won't rise as the dose goes up, with the option to pause instead of cancel.
Visit Yucca HealthThe verdict
PepHaūs takes it, leading the Cost-Efficiency Index 85 to 83. Mid-market $152/$246 pricing on both molecules, all-50 and LegitScript-verified — a clean, verified nationwide option that trades rock-bottom cost for a dependable pharmacy. Yucca Health still earns a B — Shoppers who want a flat monthly price that won't rise as the dose goes up, with the option to pause instead of cancel.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs PepHaūs.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | PepHaūs | Yucca Health |
|---|---|---|
| Cost-Efficiency Index | 85/100 | 83/100 |
| Semaglutide / mo | $152/mo | $146/moMonth to month, same price at every dose, compounded |
| Tirzepatide / mo | $246/mo | $258/moMonth to month, same price at every dose, compounded |
| Semaglutide / yr (modeled) | $1,824 | $1,752 |
| Tirzepatide / yr (modeled) | $2,952 | $3,096 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #19 | #23 |
PepHaūs
85/100Where the value is
- Both molecules disclosed at flat prices with nationwide all-50 access
- LegitScript-certified pharmacy behind the program
- Predictable pricing that's straightforward to model for a year
The tradeoffs
- $152/$246 is mid-market — undercut on raw cost by several verified all-50 rivals
- Compounded only — no brand-name or oral option
Yucca Health
83/100Where the value is
- Each product page shows all three plans: semaglutide is $146 month to month, $140 a month on three months ($420) and $125 on six ($750); tirzepatide is $258, $248 ($744) and $225 ($1,350)
- The price is locked at every dose for as long as your plan stays active, and pausing keeps the lock
- A written six-month promise refunds everything you paid, including medication, if you follow the plan for six months and haven't lost weight from your logged starting weight
The tradeoffs
- The "$125/mo for life" banner is the six-month plan, billed $750 up front; the no-commitment monthly price is $146
- Once a clinician issues your prescription that order is final and can't be refunded, and you must cancel at least 7 days before a renewal to stop it
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.